Leadlay PF - Search Results

1

Recent advances in the field of bioactive tetronates.

Vieweg L, Reichau S, Schobert R, Leadlay PF, Süssmuth RD. Vieweg L, et al. Among authors: leadlay pf. Nat Prod Rep. 2014 Nov;31(11):1554-84. doi: 10.1039/c4np00015c. Nat Prod Rep. 2014. PMID: 24965099 Review.

2

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria.

Hong H, Demangel C, Pidot SJ, Leadlay PF, Stinear T. Hong H, et al. Among authors: leadlay pf. Nat Prod Rep. 2008 Jun;25(3):447-54. doi: 10.1039/b803101k. Epub 2008 Apr 17. Nat Prod Rep. 2008. PMID: 18497894 Free PMC article. Review.

3

An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics.

Hong H, Samborskyy M, Lindner F, Leadlay PF. Hong H, et al. Among authors: leadlay pf. Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1118-23. doi: 10.1002/anie.201509300. Epub 2015 Dec 2. Angew Chem Int Ed Engl. 2016. PMID: 26630438 Free PMC article.

4

Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.

Hong H, Gates PJ, Staunton J, Stinear T, Cole ST, Leadlay PF, Spencer JB. Hong H, et al. Among authors: leadlay pf. Chem Commun (Camb). 2003 Nov 21;(22):2822-3. doi: 10.1039/b308163j. Chem Commun (Camb). 2003. PMID: 14651122

5

Engineered biosynthesis of phenyl-substituted polyketides.

Garcia-Bernardo J, Xiang L, Hong H, Moore BS, Leadlay PF. Garcia-Bernardo J, et al. Among authors: leadlay pf. Chembiochem. 2004 Aug 6;5(8):1129-31. doi: 10.1002/cbic.200400007. Chembiochem. 2004. PMID: 15300838 No abstract available.

6

A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.

Hong H, Spencer JB, Porter JL, Leadlay PF, Stinear T. Hong H, et al. Among authors: leadlay pf. Chembiochem. 2005 Apr;6(4):643-8. doi: 10.1002/cbic.200400339. Chembiochem. 2005. PMID: 15750996 No abstract available.

7

Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.

Hong H, Stinear T, Skelton P, Spencer JB, Leadlay PF. Hong H, et al. Among authors: leadlay pf. Chem Commun (Camb). 2005 Sep 14;(34):4306-8. doi: 10.1039/b506835e. Epub 2005 Aug 5. Chem Commun (Camb). 2005. PMID: 16113730

8

A novel mycolactone toxin obtained by biosynthetic engineering.

Hong H, Stinear T, Porter J, Demangel C, Leadlay PF. Hong H, et al. Among authors: leadlay pf. Chembiochem. 2007 Nov 23;8(17):2043-7. doi: 10.1002/cbic.200700411. Chembiochem. 2007. PMID: 17907121 Free PMC article. No abstract available.

9

Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones.

Pidot SJ, Hong H, Seemann T, Porter JL, Yip MJ, Men A, Johnson M, Wilson P, Davies JK, Leadlay PF, Stinear TP. Pidot SJ, et al. Among authors: leadlay pf. BMC Genomics. 2008 Oct 7;9:462. doi: 10.1186/1471-2164-9-462. BMC Genomics. 2008. PMID: 18840298 Free PMC article.

10

Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs.

Hong H, Coutanceau E, Leclerc M, Caleechurn L, Leadlay PF, Demangel C. Hong H, et al. Among authors: leadlay pf. PLoS Negl Trop Dis. 2008;2(10):e325. doi: 10.1371/journal.pntd.0000325. Epub 2008 Oct 22. PLoS Negl Trop Dis. 2008. PMID: 18941518 Free PMC article.

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