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Fluorinated N,N'-diarylureas as AMPK activators.
Sviripa V, Zhang W, Conroy MD, Schmidt ES, Liu AX, Truong J, Liu C, Watt DS. Sviripa V, et al. Among authors: zhang w. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1600-3. doi: 10.1016/j.bmcl.2013.01.096. Epub 2013 Jan 30. Bioorg Med Chem Lett. 2013. PMID: 23414799 Free PMC article.
Halogenated diarylacetylenes repress c-myc expression in cancer cells.
Sviripa VM, Zhang W, Kril LM, Liu AX, Yuan Y, Zhan CG, Liu C, Watt DS. Sviripa VM, et al. Among authors: zhang w. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3638-40. doi: 10.1016/j.bmcl.2014.04.113. Epub 2014 May 9. Bioorg Med Chem Lett. 2014. PMID: 24930834 Free PMC article.
Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis.
Burikhanov R, Sviripa VM, Hebbar N, Zhang W, Layton WJ, Hamza A, Zhan CG, Watt DS, Liu C, Rangnekar VM. Burikhanov R, et al. Among authors: zhang w. Nat Chem Biol. 2014 Nov;10(11):924-926. doi: 10.1038/nchembio.1631. Epub 2014 Sep 14. Nat Chem Biol. 2014. PMID: 25218743 Free PMC article.
Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4).
Frasinyuk MS, Zhang W, Wyrebek P, Yu T, Xu X, Sviripa VM, Bondarenko SP, Xie Y, Ngo HX, Morris AJ, Mohler JL, Fiandalo MV, Watt DS, Liu C. Frasinyuk MS, et al. Among authors: zhang w. Org Biomol Chem. 2017 Sep 20;15(36):7623-7629. doi: 10.1039/c7ob01584d. Org Biomol Chem. 2017. PMID: 28868548 Free PMC article.
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