Mutule I - Search Results

1

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.

Jaudzems K, Tars K, Maurops G, Ivdra N, Otikovs M, Leitans J, Kanepe-Lapsa I, Domraceva I, Mutule I, Trapencieris P, Blackman MJ, Jirgensons A. Jaudzems K, et al. Among authors: mutule i. ACS Med Chem Lett. 2014 Jan 13;5(4):373-7. doi: 10.1021/ml4004952. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900843 Free PMC article.

2

5-membered cyclic hydroxamic acids as HDAC inhibitors.

Mutule I, Borovika D, Rozenberga E, Romanchikova N, Zalubovskis R, Shestakova I, Trapencieris P. Mutule I, et al. J Enzyme Inhib Med Chem. 2015 Apr;30(2):216-23. doi: 10.3109/14756366.2014.912214. Epub 2014 Jun 18. J Enzyme Inhib Med Chem. 2015. PMID: 24939099 Free article.

3

New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ".

Mutulis F, Yahorava S, Mutule I, Yahorau A, Liepinsh E, Kopantshuk S, Veiksina S, Tars K, Belyakov S, Mishnev A, Rinken A, Wikberg JE. Mutulis F, et al. Among authors: mutule i. J Med Chem. 2004 Aug 26;47(18):4613-26. doi: 10.1021/jm0311285. J Med Chem. 2004. PMID: 15317471

4

Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of pi*--pi* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT(1) non-peptide antagonists.

Polevaya L, Mavromoustakos T, Zoumboulakis P, Golic Grdadolnik S, Roumelioti P, Giatas N, Mutule I, Keivish T, Vlahakos DV, Iliodromitis EK, Kremastinos DT, Matsoukas J. Polevaya L, et al. Among authors: mutule i. Bioorg Med Chem. 2001 Jun;9(6):1639-47. doi: 10.1016/s0968-0896(01)00059-1. Bioorg Med Chem. 2001. PMID: 11408184

5

Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors.

Mutulis F, Mutule I, Lapins M, Wikberg JE. Mutulis F, et al. Among authors: mutule i. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1035-8. doi: 10.1016/s0960-894x(02)00088-4. Bioorg Med Chem Lett. 2002. PMID: 11909711

6

N-alkylaminoacids and their derivatives interact with melanocortin receptors.

Mutulis F, Mutule I, Wikberg JE. Mutulis F, et al. Among authors: mutule i. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1039-42. doi: 10.1016/s0960-894x(02)00089-6. Bioorg Med Chem Lett. 2002. PMID: 11909712

7

QSAR and proteo-chemometric analysis of the interaction of a series of organic compounds with melanocortin receptor subtypes.

Lapinsh M, Prusis P, Mutule I, Mutulis F, Wikberg JE. Lapinsh M, et al. Among authors: mutule i. J Med Chem. 2003 Jun 19;46(13):2572-9. doi: 10.1021/jm020945m. J Med Chem. 2003. PMID: 12801221

8

Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.

Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE. Lapinsh M, et al. Among authors: mutule i. Mol Pharmacol. 2005 Jan;67(1):50-9. doi: 10.1124/mol.104.002857. Epub 2004 Oct 6. Mol Pharmacol. 2005. PMID: 15470082

9

Co-operative regulation of ligand binding to melanocortin receptor subtypes: evidence for interacting binding sites.

Kopanchuk S, Veiksina S, Petrovska R, Mutule I, Szardenings M, Rinken A, Wikberg JE. Kopanchuk S, et al. Among authors: mutule i. Eur J Pharmacol. 2005 Apr 11;512(2-3):85-95. doi: 10.1016/j.ejphar.2005.02.021. Eur J Pharmacol. 2005. PMID: 15840392

10

N-alkylated dipeptide amides and related structures as imitations of the melanocortins' active core.

Mutulis F, Mutule I, Liepinsh E, Yahorau A, Lapinsh M, Kopantshuk S, Veiksina S, Rinken A, Wikberg JE. Mutulis F, et al. Among authors: mutule i. Peptides. 2005 Oct;26(10):1997-2016. doi: 10.1016/j.peptides.2004.11.026. Peptides. 2005. PMID: 15985308

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