Laganas VA - Search Results

1

Antimicrobial Activity of Adenine-Based Inhibitors of NAD(+)-Dependent DNA Ligase.

Buurman ET, Laganas VA, Liu CF, Manchester JI. Buurman ET, et al. Among authors: laganas va. ACS Med Chem Lett. 2012 Jul 12;3(8):663-7. doi: 10.1021/ml300169x. eCollection 2012 Aug 9. ACS Med Chem Lett. 2012. PMID: 24900527 Free PMC article.

2

Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.

Buurman ET, Foulk MA, Gao N, Laganas VA, McKinney DC, Moustakas DT, Rose JA, Shapiro AB, Fleming PR. Buurman ET, et al. Among authors: laganas va. J Bacteriol. 2012 Oct;194(20):5504-12. doi: 10.1128/JB.01103-12. Epub 2012 Jul 27. J Bacteriol. 2012. PMID: 22843845 Free PMC article.

3

The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.

Abibi A, Ferguson AD, Fleming PR, Gao N, Hajec LI, Hu J, Laganas VA, McKinney DC, McLeod SM, Prince DB, Shapiro AB, Buurman ET. Abibi A, et al. Among authors: laganas va. J Biol Chem. 2014 Aug 1;289(31):21651-62. doi: 10.1074/jbc.M114.574061. Epub 2014 Jun 16. J Biol Chem. 2014. PMID: 24936059 Free PMC article.

4

Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.

Murphy-Benenato KE, Gingipalli L, Boriack-Sjodin PA, Martinez-Botella G, Carcanague D, Eyermann CJ, Gowravaram M, Harang J, Hale MR, Ioannidis G, Jahic H, Johnstone M, Kutschke A, Laganas VA, Loch JT 3rd, Miller MD, Oguto H, Patel SJ. Murphy-Benenato KE, et al. Among authors: laganas va. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5172-7. doi: 10.1016/j.bmcl.2015.09.075. Epub 2015 Oct 14. Bioorg Med Chem Lett. 2015. PMID: 26463129

5

Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.

de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J. de Jonge BL, et al. Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. Epub 2013 Sep 16. Antimicrob Agents Chemother. 2013. PMID: 24041904 Free PMC article.

6

Characterization of novel respiratory syncytial virus inhibitors identified by high throughput screen.

Laganas VA, Dunn EF, McLaughlin RE, Tiong-Yip CL, Yuzhakov O, Isabella VM, Hill P, Yu Q. Laganas VA, et al. Antiviral Res. 2015 Mar;115:71-4. doi: 10.1016/j.antiviral.2014.12.012. Epub 2014 Dec 24. Antiviral Res. 2015. PMID: 25542974

7

Array synthesis of novel lipodepsipeptide.

Siedlecki J, Hill J, Parr I, Yu X, Morytko M, Zhang Y, Silverman J, Controneo N, Laganas V, Li T, Li J, Keith D, Shimer G, Finn J. Siedlecki J, et al. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4245-9. doi: 10.1016/j.bmcl.2003.07.025. Bioorg Med Chem Lett. 2003. PMID: 14623010

8

Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin.

Hill J, Siedlecki J, Parr I, Morytko M, Yu X, Zhang Y, Silverman J, Controneo N, Laganas V, Li T, Lai JJ, Keith D, Shimer G, Finn J. Hill J, et al. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4187-91. doi: 10.1016/j.bmcl.2003.07.019. Bioorg Med Chem Lett. 2003. PMID: 14622998

9

In vitro bactericidal activities of daptomycin against Staphylococcus aureus and Enterococcus faecalis are not mediated by inhibition of lipoteichoic acid biosynthesis.

Laganas V, Alder J, Silverman JA. Laganas V, et al. Antimicrob Agents Chemother. 2003 Aug;47(8):2682-4. doi: 10.1128/AAC.47.8.2682-2684.2003. Antimicrob Agents Chemother. 2003. PMID: 12878541 Free PMC article.

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