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Page 1
Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.
Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Lanaspa MA, et al. Among authors: diggle cp. J Am Soc Nephrol. 2014 Nov;25(11):2526-38. doi: 10.1681/ASN.2013080901. Epub 2014 May 29. J Am Soc Nephrol. 2014. PMID: 24876114 Free PMC article.
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice.
Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ. Ishimoto T, et al. Among authors: diggle cp. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4320-5. doi: 10.1073/pnas.1119908109. Epub 2012 Feb 27. Proc Natl Acad Sci U S A. 2012. PMID: 22371574 Free PMC article.
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.
Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. Ishimoto T, et al. Among authors: diggle cp. Hepatology. 2013 Nov;58(5):1632-43. doi: 10.1002/hep.26594. Epub 2013 Oct 8. Hepatology. 2013. PMID: 23813872 Free PMC article.
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome.
Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Lanaspa MA, et al. Among authors: diggle cp. Nat Commun. 2013;4:2434. doi: 10.1038/ncomms3434. Nat Commun. 2013. PMID: 24022321 Free PMC article.
A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development.
Diggle CP, Martinez-Garay I, Molnar Z, Brinkworth MH, White E, Fowler E, Hughes R, Hayward BE, Carr IM, Watson CM, Crinnion L, Asipu A, Woodman B, Coletta PL, Markham AF, Dear TN, Bonthron DT, Peckham M, Morrison EE, Sheridan E. Diggle CP, et al. PLoS One. 2017 Apr 7;12(4):e0174264. doi: 10.1371/journal.pone.0174264. eCollection 2017. PLoS One. 2017. PMID: 28388629 Free PMC article.
45 results