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Potent inhibitors of 5-lipoxygenase identified using pseudoreceptors.
Rödl CB, Tanrikulu Y, Wisniewska JM, Proschak E, Schneider G, Steinhilber D, Hofmann B. Rödl CB, et al. Among authors: hofmann b. ChemMedChem. 2011 Jun 6;6(6):1001-5. doi: 10.1002/cmdc.201100059. Epub 2011 Apr 19. ChemMedChem. 2011. PMID: 21506275 No abstract available.
Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor.
Hofmann B, Rödl CB, Kahnt AS, Maier TJ, Michel AA, Hoffmann M, Rau O, Awwad K, Pellowska M, Wurglics M, Wacker M, Zivković A, Fleming I, Schubert-Zsilavecz M, Stark H, Schneider G, Steinhilber D. Hofmann B, et al. Br J Pharmacol. 2012 Apr;165(7):2304-13. doi: 10.1111/j.1476-5381.2011.01707.x. Br J Pharmacol. 2012. PMID: 21955369 Free PMC article.
Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor.
Wisniewska JM, Rödl CB, Kahnt AS, Buscató El, Ulrich S, Tanrikulu Y, Achenbach J, Rörsch F, Grösch S, Schneider G, Cinatl J Jr, Proschak E, Steinhilber D, Hofmann B. Wisniewska JM, et al. Among authors: hofmann b. Biochem Pharmacol. 2012 Jan 15;83(2):228-40. doi: 10.1016/j.bcp.2011.10.012. Epub 2011 Oct 18. Biochem Pharmacol. 2012. PMID: 22027220
Dimerization of human 5-lipoxygenase.
Häfner AK, Cernescu M, Hofmann B, Ermisch M, Hörnig M, Metzner J, Schneider G, Brutschy B, Steinhilber D. Häfner AK, et al. Among authors: hofmann b. Biol Chem. 2011 Dec;392(12):1097-111. doi: 10.1515/BC.2011.200. Biol Chem. 2011. PMID: 22050225
Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.
Hörnig M, Markoutsa S, Häfner AK, George S, Wisniewska JM, Rödl CB, Hofmann B, Maier T, Karas M, Werz O, Steinhilber D. Hörnig M, et al. Among authors: hofmann b. Biochim Biophys Acta. 2012 Feb;1821(2):279-86. doi: 10.1016/j.bbalip.2011.11.001. Epub 2011 Nov 23. Biochim Biophys Acta. 2012. PMID: 22137889
724 results