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Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model.
Aguiar-Alves F, Le HN, Tran VG, Gras E, Vu TTT, Dong OX, Quetz JS, Cheng LI, Yu L, Sellman BR, Stover CK, DiGiandomenico A, Diep BA. Aguiar-Alves F, et al. Among authors: stover ck. Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0202221. doi: 10.1128/AAC.02022-21. Epub 2021 Dec 13. Antimicrob Agents Chemother. 2022. PMID: 34902264 Free PMC article.
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.
DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N, Sellman BR, Hilliard J, Guenther CM, Datta V, Zhao W, Gao C, Yu XQ, Suzich JA, Stover CK. DiGiandomenico A, et al. Among authors: stover ck. Sci Transl Med. 2014 Nov 12;6(262):262ra155. doi: 10.1126/scitranslmed.3009655. Sci Transl Med. 2014. PMID: 25391481
Pseudomonas aeruginosa Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide.
Thaden JT, Keller AE, Shire NJ, Camara MM, Otterson L, Huband M, Guenther CM, Zhao W, Warrener P, Stover CK, Fowler VG Jr, DiGiandomenico A. Thaden JT, et al. Among authors: stover ck. J Infect Dis. 2016 Feb 15;213(4):640-8. doi: 10.1093/infdis/jiv436. Epub 2015 Sep 2. J Infect Dis. 2016. PMID: 26333940 Free PMC article.
Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models.
Le HN, Tran VG, Vu TTT, Gras E, Le VTM, Pinheiro MG, Aguiar-Alves F, Schneider-Smith E, Carter HC, Sellman BR, Stover CK, DiGiandomenico A, Diep BA. Le HN, et al. Among authors: stover ck. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00710-19. doi: 10.1128/AAC.00710-19. Print 2019 Aug. Antimicrob Agents Chemother. 2019. PMID: 31160288 Free PMC article.
Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening.
DiGiandomenico A, Warrener P, Hamilton M, Guillard S, Ravn P, Minter R, Camara MM, Venkatraman V, Macgill RS, Lin J, Wang Q, Keller AE, Bonnell JC, Tomich M, Jermutus L, McCarthy MP, Melnick DA, Suzich JA, Stover CK. DiGiandomenico A, et al. Among authors: stover ck. J Exp Med. 2012 Jul 2;209(7):1273-87. doi: 10.1084/jem.20120033. Epub 2012 Jun 25. J Exp Med. 2012. PMID: 22734046 Free PMC article.
Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models.
Tkaczyk C, Semenova E, Shi YY, Rosenthal K, Oganesyan V, Warrener P, Stover CK, Sellman BR. Tkaczyk C, et al. Among authors: stover ck. Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01033-18. doi: 10.1128/AAC.01033-18. Print 2018 Nov. Antimicrob Agents Chemother. 2018. PMID: 30150481 Free PMC article.
Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.
Tkaczyk C, Kasturirangan S, Minola A, Jones-Nelson O, Gunter V, Shi YY, Rosenthal K, Aleti V, Semenova E, Warrener P, Tabor D, Stover CK, Corti D, Rainey G, Sellman BR. Tkaczyk C, et al. Among authors: stover ck. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00629-17. doi: 10.1128/AAC.00629-17. Print 2017 Aug. Antimicrob Agents Chemother. 2017. PMID: 28584141 Free PMC article.
101 results