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A mixed mirror-image DNA/RNA aptamer inhibits glucagon and acutely improves glucose tolerance in models of type 1 and type 2 diabetes.
Vater A, Sell S, Kaczmarek P, Maasch C, Buchner K, Pruszynska-Oszmalek E, Kolodziejski P, Purschke WG, Nowak KW, Strowski MZ, Klussmann S. Vater A, et al. Among authors: buchner k. J Biol Chem. 2013 Jul 19;288(29):21136-21147. doi: 10.1074/jbc.M112.444414. Epub 2013 Jun 6. J Biol Chem. 2013. PMID: 23744070 Free PMC article.
Hematopoietic stem and progenitor cell mobilization in mice and humans by a first-in-class mirror-image oligonucleotide inhibitor of CXCL12.
Vater A, Sahlmann J, Kröger N, Zöllner S, Lioznov M, Maasch C, Buchner K, Vossmeyer D, Schwoebel F, Purschke WG, Vonhoff S, Kruschinski A, Hübel K, Humphrey M, Klussmann S, Fliegert F. Vater A, et al. Among authors: buchner k. Clin Pharmacol Ther. 2013 Jul;94(1):150-7. doi: 10.1038/clpt.2013.58. Epub 2013 Mar 19. Clin Pharmacol Ther. 2013. PMID: 23588307
A novel CGRP-neutralizing Spiegelmer attenuates neurogenic plasma protein extravasation.
Hoehlig K, Johnson KW, Pryazhnikov E, Maasch C, Clemens-Smith A, Purschke WG, Vauléon S, Buchner K, Jarosch F, Khiroug L, Vater A, Klussmann S. Hoehlig K, et al. Among authors: buchner k. Br J Pharmacol. 2015 Jun;172(12):3086-98. doi: 10.1111/bph.13110. Epub 2015 Mar 27. Br J Pharmacol. 2015. PMID: 25659966 Free PMC article.
An L-RNA-based aquaretic agent that inhibits vasopressin in vivo.
Purschke WG, Eulberg D, Buchner K, Vonhoff S, Klussmann S. Purschke WG, et al. Among authors: buchner k. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5173-8. doi: 10.1073/pnas.0509663103. Epub 2006 Mar 17. Proc Natl Acad Sci U S A. 2006. PMID: 16547136 Free PMC article.
91 results