Drake EJ - Search Results

1

Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine.

Wurst JM, Drake EJ, Theriault JR, Jewett IT, VerPlank L, Perez JR, Dandapani S, Palmer M, Moskowitz SM, Schreiber SL, Munoz B, Gulick AM. Wurst JM, et al. Among authors: drake ej. ACS Chem Biol. 2014 Jul 18;9(7):1536-44. doi: 10.1021/cb5001586. Epub 2014 May 21. ACS Chem Biol. 2014. PMID: 24824984 Free PMC article.

2

Structural characterization and high-throughput screening of inhibitors of PvdQ, an NTN hydrolase involved in pyoverdine synthesis.

Drake EJ, Gulick AM. Drake EJ, et al. ACS Chem Biol. 2011 Nov 18;6(11):1277-86. doi: 10.1021/cb2002973. Epub 2011 Sep 15. ACS Chem Biol. 2011. PMID: 21892836 Free PMC article.

3

Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ.

Clevenger KD, Mascarenhas R, Catlin D, Wu R, Kelleher NL, Drake EJ, Gulick AM, Liu D, Fast W. Clevenger KD, et al. Among authors: drake ej. ACS Chem Biol. 2017 Mar 17;12(3):643-647. doi: 10.1021/acschembio.7b00031. Epub 2017 Feb 15. ACS Chem Biol. 2017. PMID: 28186406 Free PMC article.

4

Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin.

Drake EJ, Gulick AM. Drake EJ, et al. J Mol Biol. 2008 Dec 5;384(1):193-205. doi: 10.1016/j.jmb.2008.09.027. Epub 2008 Sep 19. J Mol Biol. 2008. PMID: 18824174 Free PMC article.

5

1.2 Å resolution crystal structure of the periplasmic aminotransferase PvdN from Pseudomonas aeruginosa.

Drake EJ, Gulick AM. Drake EJ, et al. Acta Crystallogr F Struct Biol Commun. 2016 May;72(Pt 5):403-8. doi: 10.1107/S2053230X16006257. Epub 2016 Apr 22. Acta Crystallogr F Struct Biol Commun. 2016. PMID: 27139833 Free PMC article.

6

The 1.8 A crystal structure of PA2412, an MbtH-like protein from the pyoverdine cluster of Pseudomonas aeruginosa.

Drake EJ, Cao J, Qu J, Shah MB, Straubinger RM, Gulick AM. Drake EJ, et al. J Biol Chem. 2007 Jul 13;282(28):20425-34. doi: 10.1074/jbc.M611833200. Epub 2007 May 14. J Biol Chem. 2007. PMID: 17502378 Free article.

7

Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii.

Neres J, Engelhart CA, Drake EJ, Wilson DJ, Fu P, Boshoff HI, Barry CE 3rd, Gulick AM, Aldrich CC. Neres J, et al. Among authors: drake ej. J Med Chem. 2013 Mar 28;56(6):2385-405. doi: 10.1021/jm301709s. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23437866 Free PMC article.

8

Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae.

Bailey DC, Drake EJ, Grant TD, Gulick AM. Bailey DC, et al. Among authors: drake ej. Biochemistry. 2016 Jun 28;55(25):3559-70. doi: 10.1021/acs.biochem.6b00409. Epub 2016 Jun 16. Biochemistry. 2016. PMID: 27253399 Free PMC article.

9

Biochemical and structural characterization of bisubstrate inhibitors of BasE, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis.

Drake EJ, Duckworth BP, Neres J, Aldrich CC, Gulick AM. Drake EJ, et al. Biochemistry. 2010 Nov 2;49(43):9292-305. doi: 10.1021/bi101226n. Biochemistry. 2010. PMID: 20853905 Free PMC article.

10

Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca.

Alexander EM, Kreitler DF, Guidolin V, Hurben AK, Drake E, Villalta PW, Balbo S, Gulick AM, Aldrich CC. Alexander EM, et al. ACS Infect Dis. 2020 Jul 10;6(7):1976-1997. doi: 10.1021/acsinfecdis.0c00326. Epub 2020 Jun 24. ACS Infect Dis. 2020. PMID: 32485104 Free PMC article.

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