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Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Mehel H, et al. Among authors: nikolaev vo. J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26. J Am Coll Cardiol. 2013. PMID: 23810893 Free article.
Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.
Fischer TH, Herting J, Mason FE, Hartmann N, Watanabe S, Nikolaev VO, Sprenger JU, Fan P, Yao L, Popov AF, Danner BC, Schöndube F, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S. Fischer TH, et al. Among authors: nikolaev vo. Cardiovasc Res. 2015 Jul 1;107(1):184-96. doi: 10.1093/cvr/cvv153. Epub 2015 May 18. Cardiovasc Res. 2015. PMID: 25990311 Free PMC article.
Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.
Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Abu-Taha IH, et al. Among authors: nikolaev vo. Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852. Epub 2016 Dec 7. Circulation. 2017. PMID: 27927712 Free article.
T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure.
Schobesberger S, Wright P, Tokar S, Bhargava A, Mansfield C, Glukhov AV, Poulet C, Buzuk A, Monszpart A, Sikkel M, Harding SE, Nikolaev VO, Lyon AR, Gorelik J. Schobesberger S, et al. Among authors: nikolaev vo. Cardiovasc Res. 2017 Jun 1;113(7):770-782. doi: 10.1093/cvr/cvx074. Cardiovasc Res. 2017. PMID: 28505272 Free PMC article.
192 results