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Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin II.
Magnani F, Pappas CG, Crook T, Magafa V, Cordopatis P, Ishiguro S, Ohta N, Selent J, Bosnyak S, Jones ES, Gerothanassis IP, Tamura M, Widdop RE, Tzakos AG. Magnani F, et al. Among authors: crook t. ACS Chem Biol. 2014 Jul 18;9(7):1420-5. doi: 10.1021/cb500063y. Epub 2014 May 14. ACS Chem Biol. 2014. PMID: 24787922 Free PMC article.
Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity.
Vrettos EI, Valverde IE, Mascarin A, Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B, Bekas N, Grob NM, Stylos EΚ, Shaye H, Del Borgo M, Aguilar MI, Magnani F, Syed N, Crook T, Waqif E, Ghazaly E, Cherezov V, Widdop RE, Luchinat C, Michael-Titus AT, Mindt TL, Tzakos AG. Vrettos EI, et al. Among authors: crook t. Chemistry. 2020 Aug 21;26(47):10690-10694. doi: 10.1002/chem.202000924. Epub 2020 Jul 21. Chemistry. 2020. PMID: 32691857
Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid.
Tsiailanis AD, Renziehausen A, Kiriakidi S, Vrettos EI, Markopoulos GS, Sayyad N, Hirmiz B, Aguilar MI, Del Borgo MP, Kolettas E, Widdop RE, Mavromoustakos T, Crook T, Syed N, Tzakos AG. Tsiailanis AD, et al. Among authors: crook t. Free Radic Biol Med. 2020 Nov 20;160:391-402. doi: 10.1016/j.freeradbiomed.2020.08.007. Epub 2020 Aug 18. Free Radic Biol Med. 2020. PMID: 32822744
Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma.
Perryman R, Renziehausen A, Shaye H, Kostagianni AD, Tsiailanis AD, Thorne T, Chatziathanasiadou MV, Sivolapenko GB, El Mubarak MA, Han GW, Zarzycka B, Katritch V, Lebon G, Lo Nigro C, Lattanzio L, Morse SV, Choi JJ, O'Neill K, Kanaki Z, Klinakis A, Crook T, Cherezov V, Tzakos AG, Syed N. Perryman R, et al. Among authors: crook t. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116289119. doi: 10.1073/pnas.2116289119. Epub 2022 Aug 2. Proc Natl Acad Sci U S A. 2022. PMID: 35917342 Free PMC article.
The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention.
Renziehausen A, Wang H, Rao B, Weir L, Nigro CL, Lattanzio L, Merlano M, Vega-Rioja A, Del Carmen Fernandez-Carranco M, Hajji N, Matin R, Harwood C, Li S, Sim VR, O'Neill K, Evans A, Thompson A, Szlosarek P, Fleming C, Stebbing J, Proby C, Tzakos AG, Syed N, Crook T. Renziehausen A, et al. Among authors: crook t. Oncogene. 2019 Mar;38(13):2320-2336. doi: 10.1038/s41388-018-0563-y. Epub 2018 Nov 26. Oncogene. 2019. PMID: 30478450 Free article.
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors.
Hajji N, Garcia-Revilla J, Soto MS, Perryman R, Symington J, Quarles CC, Healey DR, Guo Y, Orta-Vázquez ML, Mateos-Cordero S, Shah K, Bomalaski J, Anichini G, Tzakos AG, Crook T, O'Neill K, Scheck AC, Venero JL, Syed N. Hajji N, et al. Among authors: crook t. J Clin Invest. 2022 Mar 15;132(6):e142137. doi: 10.1172/JCI142137. J Clin Invest. 2022. PMID: 35113813 Free PMC article.
Development of a validated LC-MS/MS method for the in vitro and in vivo quantitation of sunitinib in glioblastoma cells and cancer patients.
Chatziathanasiadou MV, Stylos EK, Giannopoulou E, Spyridaki MH, Briasoulis E, Kalofonos HP, Crook T, Syed N, Sivolapenko GB, Tzakos AG. Chatziathanasiadou MV, et al. Among authors: crook t. J Pharm Biomed Anal. 2019 Feb 5;164:690-697. doi: 10.1016/j.jpba.2018.11.030. Epub 2018 Nov 14. J Pharm Biomed Anal. 2019. PMID: 30472587 Free article.
384 results