Luo JF - Search Results

1

Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship.

Bao J, Luo JF, Qin XC, Xu XY, Zhang XY, Tu ZC, Qi SH. Bao J, et al. Among authors: luo jf. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2433-6. doi: 10.1016/j.bmcl.2014.04.028. Epub 2014 Apr 18. Bioorg Med Chem Lett. 2014. PMID: 24767845

2

New thiazole carboxamides as potent inhibitors of Akt kinases.

Chang S, Zhang Z, Zhuang X, Luo J, Cao X, Li H, Tu Z, Lu X, Ren X, Ding K. Chang S, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1208-12. doi: 10.1016/j.bmcl.2011.11.080. Epub 2011 Nov 30. Bioorg Med Chem Lett. 2012. PMID: 22172705

3

Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant.

Chang S, Zhang L, Xu S, Luo J, Lu X, Zhang Z, Xu T, Liu Y, Tu Z, Xu Y, Ren X, Geng M, Ding J, Pei D, Ding K. Chang S, et al. J Med Chem. 2012 Mar 22;55(6):2711-23. doi: 10.1021/jm201591k. Epub 2012 Mar 1. J Med Chem. 2012. PMID: 22339342

4

Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.

Li Y, Shen M, Zhang Z, Luo J, Pan X, Lu X, Long H, Wen D, Zhang F, Leng F, Li Y, Tu Z, Ren X, Ding K. Li Y, et al. J Med Chem. 2012 Nov 26;55(22):10033-46. doi: 10.1021/jm301188x. Epub 2012 Nov 1. J Med Chem. 2012. PMID: 23088644

5

Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.

Ren X, Pan X, Zhang Z, Wang D, Lu X, Li Y, Wen D, Long H, Luo J, Feng Y, Zhuang X, Zhang F, Liu J, Leng F, Lang X, Bai Y, She M, Tu Z, Pan J, Ding K. Ren X, et al. J Med Chem. 2013 Feb 14;56(3):879-94. doi: 10.1021/jm301581y. Epub 2013 Jan 28. J Med Chem. 2013. PMID: 23301703

6

Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors.

Gao M, Duan L, Luo J, Zhang L, Lu X, Zhang Y, Zhang Z, Tu Z, Xu Y, Ren X, Ding K. Gao M, et al. J Med Chem. 2013 Apr 25;56(8):3281-95. doi: 10.1021/jm301824k. Epub 2013 Apr 10. J Med Chem. 2013. PMID: 23521020

7

Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants.

Xu T, Zhang L, Xu S, Yang CY, Luo J, Ding F, Lu X, Liu Y, Tu Z, Li S, Pei D, Cai Q, Li H, Ren X, Wang S, Ding K. Xu T, et al. Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8387-90. doi: 10.1002/anie.201302313. Epub 2013 Jun 26. Angew Chem Int Ed Engl. 2013. PMID: 23804305 Free article. No abstract available.

8

Design, synthesis, and biological evaluation of 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives as new irreversible epidermal growth factor receptor inhibitors with improved pharmacokinetic properties.

Xu S, Xu T, Zhang L, Zhang Z, Luo J, Liu Y, Lu X, Tu Z, Ren X, Ding K. Xu S, et al. J Med Chem. 2013 Nov 14;56(21):8803-13. doi: 10.1021/jm4012388. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24124898

9

Identification and optimization of new dual inhibitors of B-Raf and epidermal growth factor receptor kinases for overcoming resistance against vemurafenib.

Cheng H, Chang Y, Zhang L, Luo J, Tu Z, Lu X, Zhang Q, Lu J, Ren X, Ding K. Cheng H, et al. J Med Chem. 2014 Mar 27;57(6):2692-703. doi: 10.1021/jm500007h. Epub 2014 Mar 18. J Med Chem. 2014. PMID: 24588073

10

N-(3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors.

Li Y, Cheng H, Zhang Z, Zhuang X, Luo J, Long H, Zhou Y, Xu Y, Taghipouran R, Li D, Patterson A, Smaill J, Tu Z, Wu D, Ren X, Ding K. Li Y, et al. ACS Med Chem Lett. 2015 Mar 18;6(5):543-7. doi: 10.1021/acsmedchemlett.5b00039. eCollection 2015 May 14. ACS Med Chem Lett. 2015. PMID: 26005530 Free PMC article.

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