Buckner FS - Search Results

1

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.

Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Koh CY, et al. Among authors: buckner fs. PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2775. doi: 10.1371/journal.pntd.0002775. eCollection 2014 Apr. PLoS Negl Trop Dis. 2014. PMID: 24743796 Free PMC article.

2

Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase.

Buckner FS, Verlinde CL, La Flamme AC, Van Voorhis WC. Buckner FS, et al. Antimicrob Agents Chemother. 1996 Nov;40(11):2592-7. doi: 10.1128/AAC.40.11.2592. Antimicrob Agents Chemother. 1996. PMID: 8913471 Free PMC article.

3

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.

Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Aronov AM, et al. Among authors: buckner fs. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4273-8. doi: 10.1073/pnas.96.8.4273. Proc Natl Acad Sci U S A. 1999. PMID: 10200252 Free PMC article.

4

Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei.

Buckner FS, Yokoyama K, Nguyen L, Grewal A, Erdjument-Bromage H, Tempst P, Strickland CL, Xiao L, Van Voorhis WC, Gelb MH. Buckner FS, et al. J Biol Chem. 2000 Jul 21;275(29):21870-6. doi: 10.1074/jbc.M000975200. J Biol Chem. 2000. PMID: 10749864 Free PMC article.

5

Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.

Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Bressi JC, et al. Among authors: buckner fs. J Med Chem. 2000 Nov 2;43(22):4135-50. doi: 10.1021/jm000287a. J Med Chem. 2000. PMID: 11063610

6

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH. Bressi JC, et al. Among authors: buckner fs. J Med Chem. 2001 Jun 21;44(13):2080-93. doi: 10.1021/jm000472o. J Med Chem. 2001. PMID: 11405646 Free PMC article.

7

Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase.

Buckner FS, Joubert BM, Boyle SM, Eastman RT, Verlinde CL, Matsuda SP. Buckner FS, et al. Mol Biochem Parasitol. 2003 Dec;132(2):75-81. doi: 10.1016/j.molbiopara.2003.07.004. Mol Biochem Parasitol. 2003. PMID: 14599667

8

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.

Glenn MP, Chang SY, Hucke O, Verlinde CL, Rivas K, Hornéy C, Yokoyama K, Buckner FS, Pendyala PR, Chakrabarti D, Gelb M, Van Voorhis WC, Sebti SM, Hamilton AD. Glenn MP, et al. Among authors: buckner fs. Angew Chem Int Ed Engl. 2005 Aug 5;44(31):4903-6. doi: 10.1002/anie.200500674. Angew Chem Int Ed Engl. 2005. PMID: 16007716 No abstract available.

9

The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.

Hucke O, Gelb MH, Verlinde CL, Buckner FS. Hucke O, et al. Among authors: buckner fs. J Med Chem. 2005 Aug 25;48(17):5415-8. doi: 10.1021/jm050441z. J Med Chem. 2005. PMID: 16107140 Free PMC article.

10

Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors.

Hankins EG, Gillespie JR, Aikenhead K, Buckner FS. Hankins EG, et al. Among authors: buckner fs. Mol Biochem Parasitol. 2005 Nov;144(1):68-75. doi: 10.1016/j.molbiopara.2005.08.002. Mol Biochem Parasitol. 2005. PMID: 16165233

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