Patterson AV - Search Results

1

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

Anderson RF, Yadav P, Patel D, Reynisson J, Tipparaju SR, Guise CP, Patterson AV, Denny WA, Maroz A, Shinde SS, Hay MP. Anderson RF, et al. Among authors: patterson av. Org Biomol Chem. 2014 Jun 7;12(21):3386-92. doi: 10.1039/c4ob00236a. Epub 2014 Apr 16. Org Biomol Chem. 2014. PMID: 24737463

2

Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.

Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA. Hay MP, et al. Among authors: patterson av. J Med Chem. 2003 Jan 2;46(1):169-82. doi: 10.1021/jm020367+. J Med Chem. 2003. PMID: 12502371

3

DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.

Hay MP, Pruijn FB, Gamage SA, Liyanage HD, Kovacs MS, Patterson AV, Wilson WR, Brown JM, Denny WA. Hay MP, et al. Among authors: patterson av. J Med Chem. 2004 Jan 15;47(2):475-88. doi: 10.1021/jm030399c. J Med Chem. 2004. PMID: 14711317

4

Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.

Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA. Atwell GJ, et al. Among authors: patterson av. J Med Chem. 2007 Mar 22;50(6):1197-212. doi: 10.1021/jm061062o. Epub 2007 Feb 28. J Med Chem. 2007. PMID: 17326614

5

Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

Patterson AV, Ferry DM, Edmunds SJ, Gu Y, Singleton RS, Patel K, Pullen SM, Hicks KO, Syddall SP, Atwell GJ, Yang S, Denny WA, Wilson WR. Patterson AV, et al. Clin Cancer Res. 2007 Jul 1;13(13):3922-32. doi: 10.1158/1078-0432.CCR-07-0478. Clin Cancer Res. 2007. PMID: 17606726

6

The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-411(NTR).

Singleton DC, Li D, Bai SY, Syddall SP, Smaill JB, Shen Y, Denny WA, Wilson WR, Patterson AV. Singleton DC, et al. Among authors: patterson av. Cancer Gene Ther. 2007 Dec;14(12):953-67. doi: 10.1038/sj.cgt.7701088. Epub 2007 Nov 2. Cancer Gene Ther. 2007. PMID: 17975564

7

DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.

Singleton RS, Guise CP, Ferry DM, Pullen SM, Dorie MJ, Brown JM, Patterson AV, Wilson WR. Singleton RS, et al. Among authors: patterson av. Cancer Res. 2009 May 1;69(9):3884-91. doi: 10.1158/0008-5472.CAN-08-4023. Epub 2009 Apr 14. Cancer Res. 2009. PMID: 19366798

8

Spin trapping of radicals other than the *OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase.

Shinde SS, Hay MP, Patterson AV, Denny WA, Anderson RF. Shinde SS, et al. Among authors: patterson av. J Am Chem Soc. 2009 Oct 14;131(40):14220-1. doi: 10.1021/ja906860a. J Am Chem Soc. 2009. PMID: 19772319

9

A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors.

Jameson MB, Rischin D, Pegram M, Gutheil J, Patterson AV, Denny WA, Wilson WR. Jameson MB, et al. Among authors: patterson av. Cancer Chemother Pharmacol. 2010 Mar;65(4):791-801. doi: 10.1007/s00280-009-1188-1. Epub 2009 Dec 10. Cancer Chemother Pharmacol. 2010. PMID: 20012293 Clinical Trial.

10

Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).

Shinde SS, Maroz A, Hay MP, Patterson AV, Denny WA, Anderson RF. Shinde SS, et al. Among authors: patterson av. J Am Chem Soc. 2010 Mar 3;132(8):2591-9. doi: 10.1021/ja908689f. J Am Chem Soc. 2010. PMID: 20141134

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