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Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.
Dhanya RP, Sheffler DJ, Dahl R, Davis M, Lee PS, Yang L, Nickols HH, Cho HP, Smith LH, D'Souza MS, Conn PJ, Der-Avakian A, Markou A, Cosford ND. Dhanya RP, et al. Among authors: cosford nd. J Med Chem. 2014 May 22;57(10):4154-72. doi: 10.1021/jm5000563. Epub 2014 May 9. J Med Chem. 2014. PMID: 24735492 Free PMC article.
5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
Roppe JR, Wang B, Huang D, Tehrani L, Kamenecka T, Schweiger EJ, Anderson JJ, Brodkin J, Jiang X, Cramer M, Chung J, Reyes-Manalo G, Munoz B, Cosford ND. Roppe JR, et al. Among authors: cosford nd. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. doi: 10.1016/j.bmcl.2004.05.037. Bioorg Med Chem Lett. 2004. PMID: 15225713
3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.
Tehrani LR, Smith ND, Huang D, Poon SF, Roppe JR, Seiders TJ, Chapman DF, Chung J, Cramer M, Cosford ND. Tehrani LR, et al. Among authors: cosford nd. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5061-4. doi: 10.1016/j.bmcl.2005.07.062. Epub 2005 Sep 23. Bioorg Med Chem Lett. 2005. PMID: 16183275
Preclinical studies of celastrol and acetyl isogambogic acid in melanoma.
Abbas S, Bhoumik A, Dahl R, Vasile S, Krajewski S, Cosford ND, Ronai ZA. Abbas S, et al. Among authors: cosford nd. Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6769-78. doi: 10.1158/1078-0432.CCR-07-1536. Clin Cancer Res. 2007. PMID: 18006779 Free PMC article.
103 results