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A humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors.
Paixão-Cavalcante D, Torreira E, Lindorfer MA, Rodriguez de Cordoba S, Morgan BP, Taylor RP, Llorca O, Harris CL. Paixão-Cavalcante D, et al. Among authors: rodriguez de cordoba s. J Immunol. 2014 May 15;192(10):4844-51. doi: 10.4049/jimmunol.1303131. Epub 2014 Apr 11. J Immunol. 2014. PMID: 24729617 Free PMC article.
A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.
Subías M, Tortajada A, Gastoldi S, Galbusera M, López-Perrote A, Lopez Lde J, González-Fernández FA, Villegas-Martínez A, Dominguez M, Llorca O, Noris M, Morgan BP, Rodríguez de Córdoba S. Subías M, et al. Among authors: rodriguez de cordoba s. J Immunol. 2014 Dec 1;193(11):5567-75. doi: 10.4049/jimmunol.1402013. Epub 2014 Oct 29. J Immunol. 2014. PMID: 25355917
The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.
Martínez-Barricarte R, Heurich M, López-Perrote A, Tortajada A, Pinto S, López-Trascasa M, Sánchez-Corral P, Morgan BP, Llorca O, Harris CL, Rodríguez de Córdoba S. Martínez-Barricarte R, et al. Among authors: rodriguez de cordoba s. Mol Immunol. 2015 Aug;66(2):263-73. doi: 10.1016/j.molimm.2015.03.248. Epub 2015 Apr 11. Mol Immunol. 2015. PMID: 25879158 Free PMC article.
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.
Martínez-Barricarte R, Heurich M, Valdes-Cañedo F, Vazquez-Martul E, Torreira E, Montes T, Tortajada A, Pinto S, Lopez-Trascasa M, Morgan BP, Llorca O, Harris CL, Rodríguez de Córdoba S. Martínez-Barricarte R, et al. Among authors: rodriguez de cordoba s. J Clin Invest. 2010 Oct;120(10):3702-12. doi: 10.1172/JCI43343. Epub 2010 Sep 13. J Clin Invest. 2010. PMID: 20852386 Free PMC article.
The complotype: dictating risk for inflammation and infection.
Harris CL, Heurich M, Rodriguez de Cordoba S, Morgan BP. Harris CL, et al. Among authors: rodriguez de cordoba s. Trends Immunol. 2012 Oct;33(10):513-21. doi: 10.1016/j.it.2012.06.001. Epub 2012 Jun 29. Trends Immunol. 2012. PMID: 22749446 Free PMC article. Review.
194 results