Larsson R - Search Results

1

The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.

Wang X, Stafford W, Mazurkiewicz M, Fryknäs M, Brjnic S, Zhang X, Gullbo J, Larsson R, Arnér ES, D'Arcy P, Linder S. Wang X, et al. Among authors: larsson r. Mol Pharmacol. 2014 Jun;85(6):932-45. doi: 10.1124/mol.113.091322. Epub 2014 Apr 8. Mol Pharmacol. 2014. PMID: 24714215

2

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells.

Jarvius M, Fryknäs M, D'Arcy P, Sun C, Rickardson L, Gullbo J, Haglund C, Nygren P, Linder S, Larsson R. Jarvius M, et al. Among authors: larsson r. Biochem Biophys Res Commun. 2013 Feb 8;431(2):117-23. doi: 10.1016/j.bbrc.2013.01.017. Epub 2013 Jan 11. Biochem Biophys Res Commun. 2013. PMID: 23318177

3

Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress.

Brnjic S, Mazurkiewicz M, Fryknäs M, Sun C, Zhang X, Larsson R, D'Arcy P, Linder S. Brnjic S, et al. Among authors: larsson r. Antioxid Redox Signal. 2014 Dec 10;21(17):2271-85. doi: 10.1089/ars.2013.5322. Epub 2013 Oct 17. Antioxid Redox Signal. 2014. PMID: 24011031 Free PMC article.

4

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.

Fayad W, Fryknäs M, Brnjic S, Olofsson MH, Larsson R, Linder S. Fayad W, et al. Among authors: larsson r. PLoS One. 2009 Oct 2;4(10):e7238. doi: 10.1371/journal.pone.0007238. PLoS One. 2009. PMID: 19798419 Free PMC article.

5

The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan.

Wickström M, Viktorsson K, Lundholm L, Aesoy R, Nygren H, Sooman L, Fryknäs M, Vogel LK, Lewensohn R, Larsson R, Gullbo J. Wickström M, et al. Among authors: larsson r. Biochem Pharmacol. 2010 May 1;79(9):1281-90. doi: 10.1016/j.bcp.2009.12.022. Epub 2010 Jan 11. Biochem Pharmacol. 2010. PMID: 20067771

6

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment.

Gullbo J, Fryknäs M, Rickardson L, Darcy P, Hägg M, Wickström M, Hassan S, Westman G, Brnjic S, Nygren P, Linder S, Larsson R. Gullbo J, et al. Among authors: larsson r. Biochem Pharmacol. 2011 Jul 15;82(2):139-47. doi: 10.1016/j.bcp.2011.04.003. Epub 2011 Apr 22. Biochem Pharmacol. 2011. PMID: 21531212 Free article.

7

Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties.

Fayad W, Rickardson L, Haglund C, Olofsson MH, D'Arcy P, Larsson R, Linder S, Fryknäs M. Fayad W, et al. Among authors: larsson r. Chem Biol Drug Des. 2011 Oct;78(4):547-57. doi: 10.1111/j.1747-0285.2011.01170.x. Epub 2011 Jul 29. Chem Biol Drug Des. 2011. PMID: 21726416

8

Inhibition of proteasome deubiquitinating activity as a new cancer therapy.

D'Arcy P, Brnjic S, Olofsson MH, Fryknäs M, Lindsten K, De Cesare M, Perego P, Sadeghi B, Hassan M, Larsson R, Linder S. D'Arcy P, et al. Among authors: larsson r. Nat Med. 2011 Nov 6;17(12):1636-40. doi: 10.1038/nm.2536. Nat Med. 2011. PMID: 22057347

9

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

Hernlund E, Olofsson MH, Fayad W, Fryknäs M, Lesiak-Mieczkowska K, Zhang X, Brnjic S, Schmidt V, D'Arcy P, Sjöblom T, De Milito A, Larsson R, Linder S. Hernlund E, et al. Among authors: larsson r. Eur J Cancer. 2012 Feb;48(3):396-406. doi: 10.1016/j.ejca.2011.11.013. Epub 2011 Dec 7. Eur J Cancer. 2012. PMID: 22154651

10

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system.

Felth J, Lesiak-Mieczkowska K, D'Arcy P, Haglund C, Gullbo J, Larsson R, Linder S, Bohlin L, Fryknäs M, Rickardson L. Felth J, et al. Among authors: larsson r. Invest New Drugs. 2013 Jun;31(3):587-98. doi: 10.1007/s10637-012-9902-y. Epub 2012 Nov 20. Invest New Drugs. 2013. PMID: 23179339

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