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Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock.
Dekker SE, Sillesen M, Bambakidis T, Andjelkovic AV, Jin G, Liu B, Boer C, Johansson PI, Linzel D, Halaweish I, Alam HB. Dekker SE, et al. Among authors: bambakidis t. J Surg Res. 2014 Jul;190(1):312-8. doi: 10.1016/j.jss.2014.02.049. Epub 2014 Mar 1. J Surg Res. 2014. PMID: 24694719
Addition of low-dose valproic acid to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined traumatic brain injury and hemorrhagic shock.
Halaweish I, Bambakidis T, Chang Z, Wei H, Liu B, Li Y, Bonthrone T, Srinivasan A, Bonham T, Chtraklin K, Alam HB. Halaweish I, et al. Among authors: bambakidis t. J Trauma Acute Care Surg. 2015 Dec;79(6):911-9; discussion 919. doi: 10.1097/TA.0000000000000789. J Trauma Acute Care Surg. 2015. PMID: 26680134
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