Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice.
Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, Notaridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, Calne R, Wallberg M.
Recino A, et al.
Gene Ther. 2019 Feb;26(1-2):40-56. doi: 10.1038/s41434-018-0052-5. Epub 2018 Dec 4.
Gene Ther. 2019.
PMID: 30514969
Free PMC article.