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The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, Meyer MR, Erdmann-Gilmore P, Townsend RR, Wilson RK, Ley TJ. Russler-Germain DA, et al. Among authors: young ma. Cancer Cell. 2014 Apr 14;25(4):442-54. doi: 10.1016/j.ccr.2014.02.010. Epub 2014 Mar 20. Cancer Cell. 2014. PMID: 24656771 Free PMC article.
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.
Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ. Spencer DH, et al. Among authors: young ma. Leukemia. 2015 Jun;29(6):1279-89. doi: 10.1038/leu.2015.6. Epub 2015 Jan 20. Leukemia. 2015. PMID: 25600023 Free PMC article.
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling DJ, Fulton RS, Fulton LL, Chen K, Schmidt H, Kalicki-Veizer J, Magrini VJ, Cook L, McGrath SD, Vickery TL, Wendl MC, Heath S, Watson MA, Link DC, Tomasson MH, Shannon WD, Payton JE, Kulkarni S, Westervelt P, Walter MJ, Graubert TA, Mardis ER, Wilson RK, DiPersio JF. Ding L, et al. Among authors: young ma. Nature. 2012 Jan 11;481(7382):506-10. doi: 10.1038/nature10738. Nature. 2012. PMID: 22237025 Free PMC article.
Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.
Young MA, Larson DE, Sun CW, George DR, Ding L, Miller CA, Lin L, Pawlik KM, Chen K, Fan X, Schmidt H, Kalicki-Veizer J, Cook LL, Swift GW, Demeter RT, Wendl MC, Sands MS, Mardis ER, Wilson RK, Townes TM, Ley TJ. Young MA, et al. Cell Stem Cell. 2012 May 4;10(5):570-82. doi: 10.1016/j.stem.2012.03.002. Epub 2012 Apr 26. Cell Stem Cell. 2012. PMID: 22542160 Free PMC article.
Functional genomic studies of aldo-keto reductases.
Petrash JM, Murthy BS, Young M, Morris K, Rikimaru L, Griest TA, Harter T. Petrash JM, et al. Chem Biol Interact. 2001 Jan 30;130-132(1-3):673-83. doi: 10.1016/s0009-2797(00)00258-1. Chem Biol Interact. 2001. PMID: 11306085
518 results