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Hypoxic selectivity and solubility--investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy.
Tercel M, Yang S, Atwell GJ, Smith E, Gu Y, Anderson RF, Denny WA, Wilson WR, Pruijn FB. Tercel M, et al. Among authors: gu y. Bioorg Med Chem. 2010 Jul 15;18(14):4997-5006. doi: 10.1016/j.bmc.2010.06.001. Epub 2010 Jun 8. Bioorg Med Chem. 2010. PMID: 20580559
A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.
Jamieson SM, Gu Y, Manesh DM, El-Hoss J, Jing D, Mackenzie KL, Guise CP, Foehrenbacher A, Pullen SM, Benito J, Smaill JB, Patterson AV, Mulaw MA, Konopleva M, Bohlander SK, Lock RB, Wilson WR. Jamieson SM, et al. Among authors: gu y. Biochem Pharmacol. 2014 Mar 1;88(1):36-45. doi: 10.1016/j.bcp.2013.12.019. Epub 2014 Jan 13. Biochem Pharmacol. 2014. PMID: 24434189
Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers.
Bonnet M, Hong CR, Gu Y, Anderson RF, Wilson WR, Pruijn FB, Wang J, Hicks KO, Hay MP. Bonnet M, et al. Among authors: gu y. Bioorg Med Chem. 2014 Apr 1;22(7):2123-32. doi: 10.1016/j.bmc.2014.02.039. Epub 2014 Mar 3. Bioorg Med Chem. 2014. PMID: 24650701
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