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Page 1
Dynamic Ins2 Gene Activity Defines β-Cell Maturity States.
Chu CMJ, Modi H, Ellis C, Krentz NAJ, Skovsø S, Zhao YB, Cen H, Noursadeghi N, Panzhinskiy E, Hu X, Dionne DA, Xia YH, Xuan S, Huising MO, Kieffer TJ, Lynn FC, Johnson JD. Chu CMJ, et al. Among authors: skovso s. Diabetes. 2022 Dec 1;71(12):2612-2631. doi: 10.2337/db21-1065. Diabetes. 2022. PMID: 36170671
Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain.
Page MM, Skovsø S, Cen H, Chiu AP, Dionne DA, Hutchinson DF, Lim GE, Szabat M, Flibotte S, Sinha S, Nislow C, Rodrigues B, Johnson JD. Page MM, et al. Among authors: skovso s. FASEB J. 2018 Mar;32(3):1196-1206. doi: 10.1096/fj.201700518R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29122848 Free PMC article.
This study demonstrates that changes in circulating insulin that are too fine to adversely affect glucose homeostasis nonetheless exert control over adiposity.-Page, M. M., Skovso, S., Cen, H., Chiu, A. P., Dionne, D. A., Hutchinson, D. F., Lim, G. E., Szabat, M., F …
This study demonstrates that changes in circulating insulin that are too fine to adversely affect glucose homeostasis nonetheless exert cont …
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Skovsø S, et al. Nat Commun. 2022 Feb 8;13(1):735. doi: 10.1038/s41467-022-28039-8. Nat Commun. 2022. PMID: 35136059 Free PMC article.
A causal role for hyperinsulinemia in obesity.
Templeman NM, Skovsø S, Page MM, Lim GE, Johnson JD. Templeman NM, et al. Among authors: skovso s. J Endocrinol. 2017 Mar;232(3):R173-R183. doi: 10.1530/JOE-16-0449. Epub 2017 Jan 4. J Endocrinol. 2017. PMID: 28052999 Review.
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.
Szabat M, Page MM, Panzhinskiy E, Skovsø S, Mojibian M, Fernandez-Tajes J, Bruin JE, Bround MJ, Lee JT, Xu EE, Taghizadeh F, O'Dwyer S, van de Bunt M, Moon KM, Sinha S, Han J, Fan Y, Lynn FC, Trucco M, Borchers CH, Foster LJ, Nislow C, Kieffer TJ, Johnson JD. Szabat M, et al. Among authors: skovso s. Cell Metab. 2016 Jan 12;23(1):179-93. doi: 10.1016/j.cmet.2015.10.016. Epub 2015 Nov 25. Cell Metab. 2016. PMID: 26626461 Free article.
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