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Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%.
Genes Chromosomes Cancer. 2014 Jun;53(6):524-36. doi: 10.1002/gcc.22163. Epub 2014 Mar 11.
Genes Chromosomes Cancer. 2014.
PMID: 24619868
Array-based comparative genomic hybridization detects copy number variations with prognostic relevance in 80% of ALL with normal karyotype or failed chromosome analysis.
Mühlbacher V, Haferlach T, Kern W, Zenger M, Schnittger S, Haferlach C.
Mühlbacher V, et al.
Leukemia. 2016 Feb;30(2):318-24. doi: 10.1038/leu.2015.276. Epub 2015 Oct 9.
Leukemia. 2016.
PMID: 26449660
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