Xu Z - Search Results

1

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

Yang C, Wang H, Qiao T, Yang B, Aliaga L, Qiu L, Tan W, Salameh J, McKenna-Yasek DM, Smith T, Peng L, Moore MJ, Brown RH Jr, Cai H, Xu Z. Yang C, et al. Among authors: xu z. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1121-9. doi: 10.1073/pnas.1322641111. Epub 2014 Mar 10. Proc Natl Acad Sci U S A. 2014. PMID: 24616503 Free PMC article.

2

Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis.

Wang H, Yang B, Qiu L, Yang C, Kramer J, Su Q, Guo Y, Brown RH Jr, Gao G, Xu Z. Wang H, et al. Among authors: xu z. Hum Mol Genet. 2014 Feb 1;23(3):668-81. doi: 10.1093/hmg/ddt454. Epub 2013 Sep 18. Hum Mol Genet. 2014. PMID: 24108104 Free PMC article.

3

TDP-43-The key to understanding amyotrophic lateral sclerosis.

Xu Z, Yang C. Xu Z, et al. Rare Dis. 2014 Oct 30;2(1):e944443. doi: 10.4161/21675511.2014.944443. eCollection 2014. Rare Dis. 2014. PMID: 26942097 Free PMC article.

4

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.

Yang C, Danielson EW, Qiao T, Metterville J, Brown RH Jr, Landers JE, Xu Z. Yang C, et al. Among authors: xu z. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6209-E6218. doi: 10.1073/pnas.1605964113. Epub 2016 Sep 28. Proc Natl Acad Sci U S A. 2016. PMID: 27681617 Free PMC article.

5

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice.

Yang C, Qiao T, Yu J, Wang H, Guo Y, Salameh J, Metterville J, Parsi S, Yusuf I, Brown RH, Cai H, Xu Z. Yang C, et al. Among authors: xu z. PLoS One. 2022 Feb 3;17(2):e0255710. doi: 10.1371/journal.pone.0255710. eCollection 2022. PLoS One. 2022. PMID: 35113871 Free PMC article.

6

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.

Wu CH, Fallini C, Ticozzi N, Keagle PJ, Sapp PC, Piotrowska K, Lowe P, Koppers M, McKenna-Yasek D, Baron DM, Kost JE, Gonzalez-Perez P, Fox AD, Adams J, Taroni F, Tiloca C, Leclerc AL, Chafe SC, Mangroo D, Moore MJ, Zitzewitz JA, Xu ZS, van den Berg LH, Glass JD, Siciliano G, Cirulli ET, Goldstein DB, Salachas F, Meininger V, Rossoll W, Ratti A, Gellera C, Bosco DA, Bassell GJ, Silani V, Drory VE, Brown RH Jr, Landers JE. Wu CH, et al. Nature. 2012 Aug 23;488(7412):499-503. doi: 10.1038/nature11280. Nature. 2012. PMID: 22801503 Free PMC article.

7

Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression.

Wang H, Ghosh A, Baigude H, Yang CS, Qiu L, Xia X, Zhou H, Rana TM, Xu Z. Wang H, et al. Among authors: xu z. J Biol Chem. 2008 Jun 6;283(23):15845-52. doi: 10.1074/jbc.M800834200. Epub 2008 Mar 26. J Biol Chem. 2008. PMID: 18367449 Free PMC article.

8

The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism.

Yang C, Tan W, Whittle C, Qiu L, Cao L, Akbarian S, Xu Z. Yang C, et al. Among authors: xu z. PLoS One. 2010 Dec 31;5(12):e15878. doi: 10.1371/journal.pone.0015878. PLoS One. 2010. PMID: 21209826 Free PMC article.

9

Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.

Qiu L, Qiao T, Beers M, Tan W, Wang H, Yang B, Xu Z. Qiu L, et al. Among authors: xu z. Mol Neurodegener. 2013 Jan 3;8:1. doi: 10.1186/1750-1326-8-1. Mol Neurodegener. 2013. PMID: 23281774 Free PMC article.

10

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

Borchelt DR, Lee MK, Slunt HS, Guarnieri M, Xu ZS, Wong PC, Brown RH Jr, Price DL, Sisodia SS, Cleveland DW. Borchelt DR, et al. Among authors: xu zs. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8292-6. doi: 10.1073/pnas.91.17.8292. Proc Natl Acad Sci U S A. 1994. PMID: 8058797 Free PMC article.

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