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Page 1
Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.
Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Küttner V, Bhukel A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Büttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Fröhlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. Eisenberg T, et al. Among authors: frohlich ku. Cell Metab. 2014 Mar 4;19(3):431-44. doi: 10.1016/j.cmet.2014.02.010. Cell Metab. 2014. PMID: 24606900 Free PMC article.
Induction of autophagy by spermidine promotes longevity.
Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Eisenberg T, et al. Among authors: frohlich ku. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. Nat Cell Biol. 2009. PMID: 19801973
Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.
Gross AS, Zimmermann A, Pendl T, Schroeder S, Schoenlechner H, Knittelfelder O, Lamplmayr L, Santiso A, Aufschnaiter A, Waltenstorfer D, Ortonobes Lara S, Stryeck S, Kast C, Ruckenstuhl C, Hofer SJ, Michelitsch B, Woelflingseder M, Müller R, Carmona-Gutierrez D, Madl T, Büttner S, Fröhlich KU, Shevchenko A, Eisenberg T. Gross AS, et al. Among authors: frohlich ku. J Biol Chem. 2019 Aug 9;294(32):12020-12039. doi: 10.1074/jbc.RA118.007020. Epub 2019 Jun 17. J Biol Chem. 2019. PMID: 31209110 Free PMC article.
Endonuclease G regulates budding yeast life and death.
Büttner S, Eisenberg T, Carmona-Gutierrez D, Ruli D, Knauer H, Ruckenstuhl C, Sigrist C, Wissing S, Kollroser M, Fröhlich KU, Sigrist S, Madeo F. Büttner S, et al. Among authors: frohlich ku. Mol Cell. 2007 Jan 26;25(2):233-46. doi: 10.1016/j.molcel.2006.12.021. Mol Cell. 2007. PMID: 17244531 Free article.
Ceramide triggers metacaspase-independent mitochondrial cell death in yeast.
Carmona-Gutierrez D, Reisenbichler A, Heimbucher P, Bauer MA, Braun RJ, Ruckenstuhl C, Büttner S, Eisenberg T, Rockenfeller P, Fröhlich KU, Kroemer G, Madeo F. Carmona-Gutierrez D, et al. Among authors: frohlich ku. Cell Cycle. 2011 Nov 15;10(22):3973-8. doi: 10.4161/cc.10.22.18212. Epub 2011 Nov 15. Cell Cycle. 2011. PMID: 22071627
Spermidine promotes mating and fertilization efficiency in model organisms.
Bauer MA, Carmona-Gutiérrez D, Ruckenstuhl C, Reisenbichler A, Megalou EV, Eisenberg T, Magnes C, Jungwirth H, Sinner FM, Pieber TR, Fröhlich KU, Kroemer G, Tavernarakis N, Madeo F. Bauer MA, et al. Among authors: frohlich ku. Cell Cycle. 2013 Jan 15;12(2):346-52. doi: 10.4161/cc.23199. Epub 2012 Jan 15. Cell Cycle. 2013. PMID: 23255134 Free PMC article.
Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.
Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F. Büttner S, et al. Among authors: frohlich ku. EMBO J. 2013 Nov 27;32(23):3041-54. doi: 10.1038/emboj.2013.228. Epub 2013 Oct 15. EMBO J. 2013. PMID: 24129513 Free PMC article.
Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification.
Ruckenstuhl C, Netzberger C, Entfellner I, Carmona-Gutierrez D, Kickenweiz T, Stekovic S, Gleixner C, Schmid C, Klug L, Sorgo AG, Eisenberg T, Büttner S, Mariño G, Koziel R, Jansen-Dürr P, Fröhlich KU, Kroemer G, Madeo F. Ruckenstuhl C, et al. Among authors: frohlich ku. PLoS Genet. 2014 May 1;10(5):e1004347. doi: 10.1371/journal.pgen.1004347. eCollection 2014 May. PLoS Genet. 2014. PMID: 24785424 Free PMC article.
Autophagy extends lifespan via vacuolar acidification.
Ruckenstuhl C, Netzberger C, Entfellner I, Carmona-Gutierrez D, Kickenweiz T, Stekovic S, Gleixner C, Schmid C, Klug L, Hajnal I, Sorgo AG, Eisenberg T, Büttner S, Marin O G, Koziel R, Magnes C, Sinner F, Pieber TR, Jansen-Dürr P, Fröhlich KU, Kroemer G, Madeo F. Ruckenstuhl C, et al. Among authors: frohlich ku. Microb Cell. 2014 May 5;1(5):160-162. doi: 10.15698/mic2014.05.147. Microb Cell. 2014. PMID: 28357240 Free PMC article.
62 results