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Identification of a TGF-β-miR-195 positive feedback loop in hepatocytes and its deregulation in hepatoma cells.
Wang R, Fu T, You K, Li S, Zhao N, Yang J, Zhuang SM. Wang R, et al. FASEB J. 2018 Jul;32(7):3936-3945. doi: 10.1096/fj.201701199R. Epub 2018 Feb 20. FASEB J. 2018. PMID: 29465312
These findings suggest that HDAC1-induced miR-195 down-regulation is an important mechanism for tumor cells to resist the cytostatic activity of TGF-beta, and highlight the importance of TGF-beta-Smad2/3-miR-195-Smad7 circuitry in preventing uncontrolled cell proliferation.-Wa …
These findings suggest that HDAC1-induced miR-195 down-regulation is an important mechanism for tumor cells to resist the cytostatic activit …
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