Boehm JC - Search Results

1

Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study.

Perez HL, Junnotula V, Knecht D, Nie H, Sanchez Y, Boehm JC, Booth-Genthe C, Yan H, Davis R, Callahan JF. Perez HL, et al. Among authors: boehm jc. Analyst. 2014 Apr 21;139(8):1902-12. doi: 10.1039/c3an02216a. Analyst. 2014. PMID: 24563904

2

Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.

Boehm J, Davis R, Murar CE, Li T, McCleland B, Dong S, Yan H, Kerns J, Moody CJ, Wilson AJ, Graves AP, Mentzer M, Qi H, Yonchuk J, Kou JP, Foley J, Sanchez Y, Podolin PL, Bolognese B, Booth-Genthe C, Galop M, Wolfe L, Carr R, Callahan JF. Boehm J, et al. Bioorg Med Chem. 2019 Feb 15;27(4):579-588. doi: 10.1016/j.bmc.2018.12.026. Epub 2018 Dec 21. Bioorg Med Chem. 2019. PMID: 30626555

3

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent.

Kerns JK, Busch-Petersen J, Fu W, Boehm JC, Nie H, Muratore M, Bullion A, Lin G, Li H, Davis R, Lin X, Lakdawala AS, Cousins R, Field R, Payne J, Miller DD, Bamborough P, Christopher JA, Baldwin I, Osborn RR, Yonchuk J, Webb E, Rumsey WL. Kerns JK, et al. Among authors: boehm jc. ACS Med Chem Lett. 2018 Oct 30;9(12):1164-1169. doi: 10.1021/acsmedchemlett.8b00291. eCollection 2018 Dec 13. ACS Med Chem Lett. 2018. PMID: 30613320 Free PMC article.

4

Synthesis of structural analogs of leukotriene B4 and their receptor binding activity.

Kingsbury WD, Pendrak I, Leber JD, Boehm JC, Mallet B, Sarau HM, Foley JJ, Schmidt DB, Daines RA. Kingsbury WD, et al. Among authors: boehm jc. J Med Chem. 1993 Oct 29;36(22):3308-20. doi: 10.1021/jm00074a012. J Med Chem. 1993. PMID: 8230121

5

Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist Leucettamine A and related analogues.

Boehm JC, Gleason JG, Pendrak I, Sarau HM, Schmidt DB, Foley JJ, Kingsbury WD. Boehm JC, et al. J Med Chem. 1993 Oct 29;36(22):3333-40. doi: 10.1021/jm00074a014. J Med Chem. 1993. PMID: 8230123

6

Phenoxypyrimidine inhibitors of p38alpha kinase: synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles.

Boehm JC, Bower MJ, Gallagher TF, Kassis S, Johnson SR, Adams JL. Boehm JC, et al. Bioorg Med Chem Lett. 2001 May 7;11(9):1123-6. doi: 10.1016/s0960-894x(01)00163-9. Bioorg Med Chem Lett. 2001. PMID: 11354358

7

N-Phenyl-N-purin-6-yl ureas: the design and synthesis of p38alpha MAP kinase inhibitors.

Wan Z, Boehm JC, Bower MJ, Kassis S, Lee JC, Zhao B, Adams JL. Wan Z, et al. Among authors: boehm jc. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1191-4. doi: 10.1016/s0960-894x(03)00048-9. Bioorg Med Chem Lett. 2003. PMID: 12643941

8

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.

Boehm JC, Smietana JM, Sorenson ME, Garigipati RS, Gallagher TF, Sheldrake PL, Bradbeer J, Badger AM, Laydon JT, Lee JC, Hillegass LM, Griswold DE, Breton JJ, Chabot-Fletcher MC, Adams JL. Boehm JC, et al. J Med Chem. 1996 Sep 27;39(20):3929-37. doi: 10.1021/jm960415o. J Med Chem. 1996. PMID: 8831759

9

Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity.

Adams JL, Boehm JC, Gallagher TF, Kassis S, Webb EF, Hall R, Sorenson M, Garigipati R, Griswold DE, Lee JC. Adams JL, et al. Among authors: boehm jc. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2867-70. doi: 10.1016/s0960-894x(01)00570-4. Bioorg Med Chem Lett. 2001. PMID: 11597418

10

Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis.

Badger AM, Griswold DE, Kapadia R, Blake S, Swift BA, Hoffman SJ, Stroup GB, Webb E, Rieman DJ, Gowen M, Boehm JC, Adams JL, Lee JC. Badger AM, et al. Among authors: boehm jc. Arthritis Rheum. 2000 Jan;43(1):175-83. doi: 10.1002/1529-0131(200001)43:1<175::AID-ANR22>3.0.CO;2-S. Arthritis Rheum. 2000. PMID: 10643714 Free article.

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