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Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death.
Magalhaes Moreira DR, de Oliveira AD, Teixeira de Moraes Gomes PA, de Simone CA, Villela FS, Ferreira RS, da Silva AC, dos Santos TA, Brelaz de Castro MC, Pereira VR, Leite AC. Magalhaes Moreira DR, et al. Among authors: de simone ca, de oliveira ad. Eur J Med Chem. 2014 Mar 21;75:467-78. doi: 10.1016/j.ejmech.2014.02.001. Epub 2014 Feb 3. Eur J Med Chem. 2014. PMID: 24561675
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
Moreira DR, Costa SP, Hernandes MZ, Rabello MM, de Oliveira Filho GB, de Melo CM, da Rocha LF, de Simone CA, Ferreira RS, Fradico JR, Meira CS, Guimarães ET, Srivastava RM, Pereira VR, Soares MB, Leite AC. Moreira DR, et al. Among authors: de oliveira filho gb, de simone ca, de melo cm. J Med Chem. 2012 Dec 27;55(24):10918-36. doi: 10.1021/jm301518v. Epub 2012 Dec 7. J Med Chem. 2012. PMID: 23167554
Structural design, synthesis and structure-activity relationships of thiazolidinones with enhanced anti-Trypanosoma cruzi activity.
Moreira DR, Leite AC, Cardoso MV, Srivastava RM, Hernandes MZ, Rabello MM, da Cruz LF, Ferreira RS, de Simone CA, Meira CS, Guimaraes ET, da Silva AC, dos Santos TA, Pereira VR, Soares MB. Moreira DR, et al. Among authors: de simone ca. ChemMedChem. 2014 Jan;9(1):177-88. doi: 10.1002/cmdc.201300354. Epub 2013 Nov 7. ChemMedChem. 2014. PMID: 24203393
Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi.
de Oliveira Filho GB, de Oliveira Cardoso MV, Espíndola JW, Ferreira LF, de Simone CA, Ferreira RS, Coelho PL, Meira CS, Magalhaes Moreira DR, Soares MB, Lima Leite AC. de Oliveira Filho GB, et al. Among authors: de simone ca, de oliveira cardoso mv. Bioorg Med Chem. 2015 Dec 1;23(23):7478-86. doi: 10.1016/j.bmc.2015.10.048. Epub 2015 Nov 2. Bioorg Med Chem. 2015. PMID: 26549870 Free article.
Desing and synthesis of potent anti-Trypanosoma cruzi agents new thiazoles derivatives which induce apoptotic parasite death.
da Silva EB, Oliveira E Silva DA, Oliveira AR, da Silva Mendes CH, Dos Santos TA, da Silva AC, de Castro MC, Ferreira RS, Moreira DR, Cardoso MV, de Simone CA, Pereira VR, Leite AC. da Silva EB, et al. Among authors: de simone ca, de castro mc. Eur J Med Chem. 2017 Apr 21;130:39-50. doi: 10.1016/j.ejmech.2017.02.026. Epub 2017 Feb 16. Eur J Med Chem. 2017. PMID: 28242550
Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: Significant Anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones.
Jardim GAM, Silva TL, Goulart MOF, de Simone CA, Barbosa JMC, Salomão K, de Castro SL, Bower JF, da Silva Júnior EN. Jardim GAM, et al. Among authors: de castro sl, de simone ca. Eur J Med Chem. 2017 Aug 18;136:406-419. doi: 10.1016/j.ejmech.2017.05.011. Epub 2017 May 4. Eur J Med Chem. 2017. PMID: 28521262
Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi.
Silva RS, Costa EM, Trindade UL, Teixeira DV, Pinto Mde C, Santos GL, Malta VR, De Simone CA, Pinto AV, de Castro SL. Silva RS, et al. Among authors: de castro sl, de simone ca. Eur J Med Chem. 2006 Apr;41(4):526-30. doi: 10.1016/j.ejmech.2005.12.006. Epub 2006 Feb 28. Eur J Med Chem. 2006. PMID: 16500733
On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions.
da Silva Júnior EN, de Melo IM, Diogo EB, Costa VA, de Souza Filho JD, Valença WO, Camara CA, de Oliveira RN, de Araujo AS, Emery FS, dos Santos MR, de Simone CA, Menna-Barreto RF, de Castro SL. da Silva Júnior EN, et al. Among authors: de castro sl, de melo im, de araujo as, de simone ca, de souza filho jd, de oliveira rn. Eur J Med Chem. 2012 Jun;52:304-12. doi: 10.1016/j.ejmech.2012.03.039. Epub 2012 Mar 29. Eur J Med Chem. 2012. PMID: 22483633
Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi.
da Silva EN Jr, Menna-Barreto RF, Pinto Mdo C, Silva RS, Teixeira DV, de Souza MC, De Simone CA, De Castro SL, Ferreira VF, Pinto AV. da Silva EN Jr, et al. Among authors: de castro sl, de simone ca, de souza mc. Eur J Med Chem. 2008 Aug;43(8):1774-80. doi: 10.1016/j.ejmech.2007.10.015. Epub 2007 Oct 22. Eur J Med Chem. 2008. PMID: 18045742
81 results