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Page 1
Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death.
Magalhaes Moreira DR, de Oliveira AD, Teixeira de Moraes Gomes PA, de Simone CA, Villela FS, Ferreira RS, da Silva AC, dos Santos TA, Brelaz de Castro MC, Pereira VR, Leite AC. Magalhaes Moreira DR, et al. Among authors: villela fs. Eur J Med Chem. 2014 Mar 21;75:467-78. doi: 10.1016/j.ejmech.2014.02.001. Epub 2014 Feb 3. Eur J Med Chem. 2014. PMID: 24561675
Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.
Espíndola JW, Cardoso MV, Filho GB, Oliveira E Silva DA, Moreira DR, Bastos TM, Simone CA, Soares MB, Villela FS, Ferreira RS, Castro MC, Pereira VR, Murta SM, Sales Junior PA, Romanha AJ, Leite AC. Espíndola JW, et al. Among authors: villela fs. Eur J Med Chem. 2015 Aug 28;101:818-35. doi: 10.1016/j.ejmech.2015.06.048. Epub 2015 Jul 3. Eur J Med Chem. 2015. PMID: 26231082
2-(phenylthio)ethylidene derivatives as anti-Trypanosoma cruzi compounds: Structural design, synthesis and antiparasitic activity.
Cardoso MVO, Oliveira Filho GB, Siqueira LRP, Espíndola JWP, Silva EBD, Mendes APO, Pereira VRA, Castro MCAB, Ferreira RS, Villela FS, Costa FMRD, Meira CS, Moreira DRM, Soares MBP, Leite ACL. Cardoso MVO, et al. Among authors: villela fs. Eur J Med Chem. 2019 Oct 15;180:191-203. doi: 10.1016/j.ejmech.2019.07.018. Epub 2019 Jul 7. Eur J Med Chem. 2019. PMID: 31306906
Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.
Pereira GAN, da Silva EB, Braga SFP, Leite PG, Martins LC, Vieira RP, Soh WT, Villela FS, Costa FMR, Ray D, de Andrade SF, Brandstetter H, Oliveira RB, Caffrey CR, Machado FS, Ferreira RS. Pereira GAN, et al. Among authors: villela fs. Eur J Med Chem. 2019 Oct 1;179:765-778. doi: 10.1016/j.ejmech.2019.06.062. Epub 2019 Jun 22. Eur J Med Chem. 2019. PMID: 31284086 Free PMC article.
Benzimidazole inhibitors of the major cysteine protease of Trypanosoma brucei.
Pereira GA, Santos LH, Wang SC, Martins LC, Villela FS, Liao W, Dessoy MA, Dias LC, Andricopulo AD, Costa MA, Nagem RA, Caffrey CR, Liedl KR, Caffarena ER, Ferreira RS. Pereira GA, et al. Among authors: villela fs. Future Med Chem. 2019 Jul;11(13):1537-1551. doi: 10.4155/fmc-2018-0523. Future Med Chem. 2019. PMID: 31469332 Free PMC article.
Zirconium catalyzed synthesis of 2-arylidene Indan-1,3-diones and evaluation of their inhibitory activity against NS2B-NS3 WNV protease.
Oliveira AFCDS, de Souza APM, de Oliveira AS, da Silva ML, de Oliveira FM, Santos EG, da Silva ÍEP, Ferreira RS, Villela FS, Martins FT, Leal DHS, Vaz BG, Teixeira RR, de Paula SO. Oliveira AFCDS, et al. Among authors: villela fs. Eur J Med Chem. 2018 Apr 10;149:98-109. doi: 10.1016/j.ejmech.2018.02.037. Epub 2018 Feb 22. Eur J Med Chem. 2018. PMID: 29499491