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mHERC6 is the essential ISG15 E3 ligase in the murine system.
Ketscher L, Basters A, Prinz M, Knobeloch KP. Ketscher L, et al. Among authors: basters a. Biochem Biophys Res Commun. 2012 Jan 6;417(1):135-40. doi: 10.1016/j.bbrc.2011.11.071. Epub 2011 Nov 23. Biochem Biophys Res Commun. 2012. PMID: 22138649
Structural basis of the specificity of USP18 toward ISG15.
Basters A, Geurink PP, Röcker A, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP, Fritz G. Basters A, et al. Nat Struct Mol Biol. 2017 Mar;24(3):270-278. doi: 10.1038/nsmb.3371. Epub 2017 Feb 6. Nat Struct Mol Biol. 2017. PMID: 28165509 Free PMC article.
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.
Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP. Ketscher L, et al. Among authors: basters a. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605921 Free PMC article.
USP18 lack in microglia causes destructive interferonopathy of the mouse brain.
Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M. Goldmann T, et al. Among authors: basters a. EMBO J. 2015 Jun 12;34(12):1612-29. doi: 10.15252/embj.201490791. Epub 2015 Apr 20. EMBO J. 2015. PMID: 25896511 Free PMC article.
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