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Cortactin, another player in the Lyn signaling pathway, is over-expressed and alternatively spliced in leukemic cells from patients with B-cell chronic lymphocytic leukemia.
Gattazzo C, Martini V, Frezzato F, Trimarco V, Tibaldi E, Castelli M, Facco M, Zonta F, Brunati AM, Zambello R, Semenzato G, Trentin L. Gattazzo C, et al. Haematologica. 2014 Jun;99(6):1069-77. doi: 10.3324/haematol.2013.090183. Epub 2014 Feb 14. Haematologica. 2014. PMID: 24532043 Free PMC article.
Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia.
Trentin L, Frasson M, Donella-Deana A, Frezzato F, Pagano MA, Tibaldi E, Gattazzo C, Zambello R, Semenzato G, Brunati AM. Trentin L, et al. Among authors: gattazzo c. Blood. 2008 Dec 1;112(12):4665-74. doi: 10.1182/blood-2008-02-139139. Epub 2008 Sep 2. Blood. 2008. PMID: 18768392 Free article.
Lack of expression of inhibitory KIR3DL1 receptor in patients with natural killer cell-type lymphoproliferative disease of granular lymphocytes.
Gattazzo C, Teramo A, Miorin M, Scquizzato E, Cabrelle A, Balsamo M, Agostini C, Vendrame E, Facco M, Albergoni MP, Trentin L, Vitale M, Semenzato G, Zambello R. Gattazzo C, et al. Haematologica. 2010 Oct;95(10):1722-9. doi: 10.3324/haematol.2010.023358. Epub 2010 Apr 21. Haematologica. 2010. PMID: 20410181 Free PMC article.
HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimen.
Frezzato F, Gattazzo C, Martini V, Trimarco V, Teramo A, Carraro S, Cabrelle A, Ave E, Facco M, Zambello R, Tibaldi E, Brunati AM, Semenzato G, Trentin L. Frezzato F, et al. Among authors: gattazzo c. PLoS One. 2012;7(6):e39902. doi: 10.1371/journal.pone.0039902. Epub 2012 Jun 29. PLoS One. 2012. PMID: 22768161 Free PMC article.
Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole.
Frezzato F, Trimarco V, Martini V, Gattazzo C, Ave E, Visentin A, Cabrelle A, Olivieri V, Zambello R, Facco M, Zonta F, Cristiani A, Brunati AM, Moro S, Semenzato G, Trentin L. Frezzato F, et al. Among authors: gattazzo c. Br J Haematol. 2014 Jun;165(5):659-72. doi: 10.1111/bjh.12815. Epub 2014 Mar 7. Br J Haematol. 2014. PMID: 24606526 Free article.
Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival.
Trimarco V, Ave E, Facco M, Chiodin G, Frezzato F, Martini V, Gattazzo C, Lessi F, Giorgi CA, Visentin A, Castelli M, Severin F, Zambello R, Piazza F, Semenzato G, Trentin L. Trimarco V, et al. Among authors: gattazzo c. Oncotarget. 2015 Dec 8;6(39):42130-49. doi: 10.18632/oncotarget.6239. Oncotarget. 2015. PMID: 26517523 Free PMC article.
Cortactin, a Lyn substrate, is a checkpoint molecule at the intersection of BCR and CXCR4 signalling pathway in chronic lymphocytic leukaemia cells.
Martini V, Gattazzo C, Frezzato F, Trimarco V, Pizzi M, Chiodin G, Severin F, Scomazzon E, Guzzardo V, Saraggi D, Raggi F, Martinello L, Facco M, Visentin A, Piazza F, Brunati AM, Semenzato G, Trentin L. Martini V, et al. Among authors: gattazzo c. Br J Haematol. 2017 Jul;178(1):81-93. doi: 10.1111/bjh.14642. Epub 2017 Apr 17. Br J Haematol. 2017. PMID: 28419476 Free article.
25 results