Friggeri L - Search Results

1

Design, synthesis and evaluation of 3,4-dihydroxybenzoic acid derivatives as antioxidants, bio-metal chelating agents and acetylcholinesterase inhibitors.

Friggeri L, De Vita D, Pandolfi F, Tortorella S, Costi R, Di Santo R, Scipione L. Friggeri L, et al. J Enzyme Inhib Med Chem. 2015 Feb;30(1):166-72. doi: 10.3109/14756366.2013.866657. Epub 2014 Feb 11. J Enzyme Inhib Med Chem. 2015. PMID: 24517367 Free article.

2

Pharmacophore assessment through 3-D QSAR: evaluation of the predictive ability on new derivatives by the application on a series of antitubercular agents.

Friggeri L, Ballante F, Ragno R, Musmuca I, De Vita D, Manetti F, Biava M, Scipione L, Di Santo R, Costi R, Feroci M, Tortorella S. Friggeri L, et al. J Chem Inf Model. 2013 Jun 24;53(6):1463-74. doi: 10.1021/ci400132q. Epub 2013 May 17. J Chem Inf Model. 2013. PMID: 23617317

3

Activity of caffeic acid derivatives against Candida albicans biofilm.

De Vita D, Friggeri L, D'Auria FD, Pandolfi F, Piccoli F, Panella S, Palamara AT, Simonetti G, Scipione L, Di Santo R, Costi R, Tortorella S. De Vita D, et al. Among authors: friggeri l. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1502-5. doi: 10.1016/j.bmcl.2014.02.005. Epub 2014 Feb 13. Bioorg Med Chem Lett. 2014. PMID: 24582984

4

New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.

Friggeri L, Scipione L, Costi R, Kaiser M, Moraca F, Zamperini C, Botta B, Di Santo R, De Vita D, Brun R, Tortorella S. Friggeri L, et al. ACS Med Chem Lett. 2013 May 7;4(6):538-41. doi: 10.1021/ml400039r. eCollection 2013 Jun 13. ACS Med Chem Lett. 2013. PMID: 24900706 Free PMC article.

5

Efficient electrochemical N-alkylation of N-boc-protected 4-aminopyridines: towards new biologically active compounds.

Feroci M, Chiarotto I, Forte G, Simonetti G, D'Auria FD, Maes L, De Vita D, Scipione L, Friggeri L, Di Santo R, Tortorella S. Feroci M, et al. Among authors: friggeri l. ISRN Org Chem. 2014 Mar 5;2014:621592. doi: 10.1155/2014/621592. eCollection 2014. ISRN Org Chem. 2014. PMID: 24955255 Free PMC article.

6

Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition.

Friggeri L, Hargrove TY, Rachakonda G, Williams AD, Wawrzak Z, Di Santo R, De Vita D, Waterman MR, Tortorella S, Villalta F, Lepesheva GI. Friggeri L, et al. J Med Chem. 2014 Aug 14;57(15):6704-17. doi: 10.1021/jm500739f. Epub 2014 Jul 29. J Med Chem. 2014. PMID: 25033013 Free PMC article.

7

Discovery of in vitro antitubercular agents through in silico ligand-based approaches.

De Vita D, Pandolfi F, Cirilli R, Scipione L, Di Santo R, Friggeri L, Mori M, Fiorucci D, Maccari G, Arul Christopher RS, Zamperini C, Pau V, De Logu A, Tortorella S, Botta M. De Vita D, et al. Among authors: friggeri l. Eur J Med Chem. 2016 Oct 4;121:169-180. doi: 10.1016/j.ejmech.2016.05.032. Epub 2016 May 20. Eur J Med Chem. 2016. PMID: 27240272

8

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.

Friggeri L, Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI. Friggeri L, et al. J Med Chem. 2019 Nov 27;62(22):10391-10401. doi: 10.1021/acs.jmedchem.9b01485. Epub 2019 Nov 11. J Med Chem. 2019. PMID: 31663733 Free PMC article.

9

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.

Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI. Friggeri L, et al. J Med Chem. 2018 Jul 12;61(13):5679-5691. doi: 10.1021/acs.jmedchem.8b00641. Epub 2018 Jun 25. J Med Chem. 2018. PMID: 29894182 Free PMC article.

10

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design.

Hargrove TY, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya EM, Hiebert SW, Guengerich FP, Waterman MR, Lepesheva GI. Hargrove TY, et al. Among authors: friggeri l. J Lipid Res. 2016 Aug;57(8):1552-63. doi: 10.1194/jlr.M069229. Epub 2016 Jun 16. J Lipid Res. 2016. PMID: 27313059 Free PMC article.

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