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STIM1 dimers undergo unimolecular coupling to activate Orai1 channels.
Zhou Y, Wang X, Wang X, Loktionova NA, Cai X, Nwokonko RM, Vrana E, Wang Y, Rothberg BS, Gill DL. Zhou Y, et al. Among authors: wang x, wang y. Nat Commun. 2015 Sep 24;6:8395. doi: 10.1038/ncomms9395. Nat Commun. 2015. PMID: 26399906 Free PMC article.
The STIM1-binding site nexus remotely controls Orai1 channel gating.
Zhou Y, Cai X, Loktionova NA, Wang X, Nwokonko RM, Wang X, Wang Y, Rothberg BS, Trebak M, Gill DL. Zhou Y, et al. Among authors: wang x, wang y. Nat Commun. 2016 Dec 8;7:13725. doi: 10.1038/ncomms13725. Nat Commun. 2016. PMID: 27929067 Free PMC article.
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