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A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling.
Köhler A, Demir U, Kickstein E, Krauss S, Aigner J, Aranda-Orgillés B, Karagiannidis AI, Achmüller C, Bu H, Wunderlich A, Schweiger MR, Schaefer G, Schweiger S, Klocker H, Schneider R. Köhler A, et al. Among authors: schweiger mr, schweiger s. Mol Cancer. 2014 Jun 9;13:146. doi: 10.1186/1476-4598-13-146. Mol Cancer. 2014. PMID: 24913494 Free PMC article.
The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.
Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S. Schweiger S, et al. J Biol Chem. 2014 Nov 14;289(46):31805-31817. doi: 10.1074/jbc.M113.541219. Epub 2014 Oct 2. J Biol Chem. 2014. PMID: 25278022 Free PMC article.
Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1).
Aranda-Orgillés B, Rutschow D, Zeller R, Karagiannidis AI, Köhler A, Chen C, Wilson T, Krause S, Roepcke S, Lilley D, Schneider R, Schweiger S. Aranda-Orgillés B, et al. Among authors: schweiger s. J Biol Chem. 2011 Nov 18;286(46):39945-57. doi: 10.1074/jbc.M111.224451. Epub 2011 Sep 19. J Biol Chem. 2011. PMID: 21930711 Free PMC article.
124 results