Yu H - Search Results

1

Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.

Koilkonda RD, Yu H, Chou TH, Feuer WJ, Ruggeri M, Porciatti V, Tse D, Hauswirth WW, Chiodo V, Boye SL, Lewin AS, Neuringer M, Renner L, Guy J. Koilkonda RD, et al. Among authors: yu h. JAMA Ophthalmol. 2014 Apr 1;132(4):409-20. doi: 10.1001/jamaophthalmol.2013.7630. JAMA Ophthalmol. 2014. PMID: 24457989 Free PMC article. Clinical Trial.

2

Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.

Yu H, Koilkonda RD, Chou TH, Porciatti V, Ozdemir SS, Chiodo V, Boye SL, Boye SE, Hauswirth WW, Lewin AS, Guy J. Yu H, et al. Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1238-47. doi: 10.1073/pnas.1119577109. Epub 2012 Apr 20. Proc Natl Acad Sci U S A. 2012. PMID: 22523243 Free PMC article.

3

Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice.

Yu H, Ozdemir SS, Koilkonda RD, Chou TH, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Lewin AS, Guy J. Yu H, et al. Mol Vis. 2012;18:1668-83. Epub 2012 Jun 20. Mol Vis. 2012. PMID: 22773905 Free PMC article.

4

NADH-dehydrogenase type-2 suppresses irreversible visual loss and neurodegeneration in the EAE animal model of MS.

Talla V, Yu H, Chou TH, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Lewin AS, Guy J. Talla V, et al. Among authors: yu h. Mol Ther. 2013 Oct;21(10):1876-88. doi: 10.1038/mt.2013.104. Epub 2013 Jun 11. Mol Ther. 2013. PMID: 23752309 Free PMC article.

5

Next-generation sequencing of mitochondrial targeted AAV transfer of human ND4 in mice.

Yu H, Mehta A, Wang G, Hauswirth WW, Chiodo V, Boye SL, Guy J. Yu H, et al. Mol Vis. 2013 Jul 14;19:1482-91. Print 2013. Mol Vis. 2013. PMID: 23869167 Free PMC article.

6

LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile.

Koilkonda R, Yu H, Talla V, Porciatti V, Feuer WJ, Hauswirth WW, Chiodo V, Erger KE, Boye SL, Lewin AS, Conlon TJ, Renner L, Neuringer M, Detrisac C, Guy J. Koilkonda R, et al. Among authors: yu h. Invest Ophthalmol Vis Sci. 2014 Oct 23;55(12):7739-53. doi: 10.1167/iovs.14-15388. Invest Ophthalmol Vis Sci. 2014. PMID: 25342621 Free PMC article.

7

Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.

Yu H, Koilkonda RD, Chou TH, Porciatti V, Mehta A, Hentall ID, Chiodo VA, Boye SL, Hauswirth WW, Lewin AS, Guy J. Yu H, et al. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5689-98. doi: 10.1073/pnas.1506129112. Epub 2015 Oct 5. Proc Natl Acad Sci U S A. 2015. PMID: 26438859 Free PMC article.

8

Longterm Reversal of Severe Visual Loss by Mitochondrial Gene Transfer in a Mouse Model of Leber Hereditary Optic Neuropathy.

Yu H, Porciatti V, Lewin A, Hauswirth W, Guy J. Yu H, et al. Sci Rep. 2018 Apr 3;8(1):5587. doi: 10.1038/s41598-018-23836-y. Sci Rep. 2018. PMID: 29615737 Free PMC article.

9

Mitochondrial Transfer of the Mutant Human ND6T14484C Gene Causes Visual Loss and Optic Neuropathy.

Yu H, Sant DW, Wang G, Guy J. Yu H, et al. Transl Vis Sci Technol. 2020 Oct 1;9(11):1. doi: 10.1167/tvst.9.11.1. eCollection 2020 Oct. Transl Vis Sci Technol. 2020. PMID: 33101779 Free PMC article.

10

Leber Hereditary Optic Neuropathy Gene Therapy: Adverse Events and Visual Acuity Results of All Patient Groups.

Lam BL, Feuer WJ, Davis JL, Porciatti V, Yu H, Levy RB, Vanner E, Guy J. Lam BL, et al. Among authors: yu h. Am J Ophthalmol. 2022 Sep;241:262-271. doi: 10.1016/j.ajo.2022.02.023. Epub 2022 Mar 7. Am J Ophthalmol. 2022. PMID: 35271811 Free PMC article.

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