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4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.
Al Rahim M, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y, Yamakuni T. Al Rahim M, et al. Among authors: tomioka y. Biochemistry. 2009 Aug 18;48(32):7713-21. doi: 10.1021/bi901088w. Biochemistry. 2009. PMID: 19601643
Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.
Saigusa D, Shiba K, Inoue A, Hama K, Okutani M, Iida N, Saito M, Suzuki K, Kaneko T, Suzuki N, Yamaguchi H, Mano N, Goto J, Hishinuma T, Aoki J, Tomioka Y. Saigusa D, et al. Among authors: tomioka y. Anal Bioanal Chem. 2012 Jun;403(7):1897-905. doi: 10.1007/s00216-012-6004-9. Epub 2012 Apr 27. Anal Bioanal Chem. 2012. PMID: 22538778
Identification of novel biomarkers of hepatocellular carcinoma by high-definition mass spectrometry: Ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging.
Nagai K, Uranbileg B, Chen Z, Fujioka A, Yamazaki T, Matsumoto Y, Tsukamoto H, Ikeda H, Yatomi Y, Chiba H, Hui SP, Nakazawa T, Saito R, Koshiba S, Aoki J, Saigusa D, Tomioka Y. Nagai K, et al. Among authors: tomioka y. Rapid Commun Mass Spectrom. 2020 Apr;34 Suppl 1(Suppl 1):e8551. doi: 10.1002/rcm.8551. Epub 2019 Nov 6. Rapid Commun Mass Spectrom. 2020. PMID: 31412144 Free PMC article.
High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound.
Saigusa D, Shibuya M, Jinno D, Yamakoshi H, Iwabuchi Y, Yokosuka A, Mimaki Y, Naganuma A, Ohizumi Y, Tomioka Y, Yamakuni T. Saigusa D, et al. Among authors: tomioka y. Anal Bioanal Chem. 2011 Jul;400(10):3635-41. doi: 10.1007/s00216-011-5031-2. Epub 2011 May 11. Anal Bioanal Chem. 2011. PMID: 21559759
402 results