Chreifi G - Search Results

1

Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.

Huang H, Li H, Yang S, Chreifi G, Martásek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB. Huang H, et al. Among authors: chreifi g. J Med Chem. 2014 Feb 13;57(3):686-700. doi: 10.1021/jm401252e. Epub 2014 Jan 30. J Med Chem. 2014. PMID: 24447275 Free PMC article.

2

Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.

Jing Q, Li H, Chreifi G, Roman LJ, Martásek P, Poulos TL, Silverman RB. Jing Q, et al. Among authors: chreifi g. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5674-9. doi: 10.1016/j.bmcl.2013.08.034. Epub 2013 Aug 14. Bioorg Med Chem Lett. 2013. PMID: 23993333 Free PMC article.

3

Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.

Cinelli MA, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Cinelli MA, et al. Among authors: chreifi g. J Med Chem. 2014 Feb 27;57(4):1513-30. doi: 10.1021/jm401838x. Epub 2014 Feb 10. J Med Chem. 2014. PMID: 24472039 Free PMC article.

4

Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.

Kang S, Tang W, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Kang S, et al. Among authors: chreifi g. J Med Chem. 2014 May 22;57(10):4382-96. doi: 10.1021/jm5004182. Epub 2014 May 7. J Med Chem. 2014. PMID: 24758147 Free PMC article.

5

Structures of human constitutive nitric oxide synthases.

Li H, Jamal J, Plaza C, Pineda SH, Chreifi G, Jing Q, Cinelli MA, Silverman RB, Poulos TL. Li H, et al. Among authors: chreifi g. Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2667-74. doi: 10.1107/S1399004714017064. Epub 2014 Sep 27. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 25286850 Free PMC article.

6

Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.

Mukherjee P, Li H, Sevrioukova I, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB. Mukherjee P, et al. Among authors: chreifi g. J Med Chem. 2015 Feb 12;58(3):1067-88. doi: 10.1021/jm501719e. Epub 2014 Dec 29. J Med Chem. 2015. PMID: 25489882 Free PMC article.

7

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.

Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB. Cinelli MA, et al. Among authors: chreifi g. J Med Chem. 2017 May 11;60(9):3958-3978. doi: 10.1021/acs.jmedchem.7b00259. Epub 2017 Apr 19. J Med Chem. 2017. PMID: 28422508 Free PMC article.

8

Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.

Pensa AV, Cinelli MA, Li H, Chreifi G, Mukherjee P, Roman LJ, Martásek P, Poulos TL, Silverman RB. Pensa AV, et al. Among authors: chreifi g. J Med Chem. 2017 Aug 24;60(16):7146-7165. doi: 10.1021/acs.jmedchem.7b00835. Epub 2017 Aug 4. J Med Chem. 2017. PMID: 28776992 Free PMC article.

9

Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.

Do HT, Wang HY, Li H, Chreifi G, Poulos TL, Silverman RB. Do HT, et al. Among authors: chreifi g. J Med Chem. 2017 Nov 22;60(22):9360-9375. doi: 10.1021/acs.jmedchem.7b01356. Epub 2017 Nov 1. J Med Chem. 2017. PMID: 29091437 Free PMC article.

10

Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides.

Li H, Evenson RJ, Chreifi G, Silverman RB, Poulos TL. Li H, et al. Among authors: chreifi g. Biochemistry. 2018 Nov 6;57(44):6319-6325. doi: 10.1021/acs.biochem.8b00895. Epub 2018 Oct 24. Biochemistry. 2018. PMID: 30335983 Free PMC article.

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