Kasprzyk PG - Search Results

1

Synthesis, antitubulin, and antiproliferative SAR of C3/C1-substituted tetrahydroisoquinolines.

Dohle W, Leese MP, Jourdan FL, Major MR, Bai R, Hamel E, Ferrandis E, Kasprzyk PG, Fiore A, Newman SP, Purohit A, Potter BV. Dohle W, et al. Among authors: kasprzyk pg. ChemMedChem. 2014 Feb;9(2):350-70. doi: 10.1002/cmdc.201300412. Epub 2014 Jan 16. ChemMedChem. 2014. PMID: 24436228

2

3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.

Bubert C, Leese MP, Mahon MF, Ferrandis E, Regis-Lydi S, Kasprzyk PG, Newman SP, Ho YT, Purohit A, Reed MJ, Potter BV. Bubert C, et al. Among authors: kasprzyk pg. J Med Chem. 2007 Sep 6;50(18):4431-43. doi: 10.1021/jm070405v. Epub 2007 Aug 15. J Med Chem. 2007. PMID: 17696419

3

Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors.

Leese MP, Jourdan FL, Major MR, Dohle W, Hamel E, Ferrandis E, Fiore A, Kasprzyk PG, Potter BV. Leese MP, et al. Among authors: kasprzyk pg. ChemMedChem. 2014 Jan;9(1):85-108, 1. doi: 10.1002/cmdc.201300261. Epub 2013 Oct 9. ChemMedChem. 2014. PMID: 24124095 Free PMC article.

4

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.

Dohle W, Jourdan FL, Menchon G, Prota AE, Foster PA, Mannion P, Hamel E, Thomas MP, Kasprzyk PG, Ferrandis E, Steinmetz MO, Leese MP, Potter BVL. Dohle W, et al. Among authors: kasprzyk pg. J Med Chem. 2018 Feb 8;61(3):1031-1044. doi: 10.1021/acs.jmedchem.7b01474. Epub 2018 Jan 8. J Med Chem. 2018. PMID: 29227648

5

The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers.

Newman SP, Foster PA, Ho YT, Day JM, Raobaikady B, Kasprzyk PG, Leese MP, Potter BV, Reed MJ, Purohit A. Newman SP, et al. Among authors: kasprzyk pg. Br J Cancer. 2007 Dec 17;97(12):1673-82. doi: 10.1038/sj.bjc.6604100. Epub 2007 Nov 20. Br J Cancer. 2007. PMID: 18026194 Free PMC article.

6

2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique.

Foster PA, Ho YT, Newman SP, Kasprzyk PG, Leese MP, Potter BV, Reed MJ, Purohit A. Foster PA, et al. Among authors: kasprzyk pg. Breast Cancer Res Treat. 2008 Sep;111(2):251-60. doi: 10.1007/s10549-007-9791-5. Epub 2007 Oct 24. Breast Cancer Res Treat. 2008. PMID: 17957467

7

STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1)/SV40 T/t-antigen transgenic mice.

Meyer-Losic F, Newman SP, Day JM, Reed MJ, Kasprzyk PG, Purohit A, Foster PA. Meyer-Losic F, et al. Among authors: kasprzyk pg. PLoS One. 2013 Dec 6;8(12):e80305. doi: 10.1371/journal.pone.0080305. eCollection 2013. PLoS One. 2013. PMID: 24324595 Free PMC article.

8

IRC-083927 is a new tubulin binder that inhibits growth of human tumor cells resistant to standard tubulin-binding agents.

Liberatore AM, Coulomb H, Pons D, Dutruel O, Kasprzyk PG, Carlson M, Nelson AS, Newman SP, Stengel C, Auvray P, Hesry V, Foll B, Narboux N, Morlais D, Le Moing M, Bernetiere S, Dellile R, Camara J, Ferrandis E, Bigg DC, Prévost GP. Liberatore AM, et al. Among authors: kasprzyk pg. Mol Cancer Ther. 2008 Aug;7(8):2426-34. doi: 10.1158/1535-7163.MCT-08-0208. Mol Cancer Ther. 2008. PMID: 18723488

9

Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex.

Prévost GP, Lonchampt MO, Holbeck S, Attoub S, Zaharevitz D, Alley M, Wright J, Brezak MC, Coulomb H, Savola A, Huchet M, Chaumeron S, Nguyen QD, Forgez P, Bruyneel E, Bracke M, Ferrandis E, Roubert P, Demarquay D, Gespach C, Kasprzyk PG. Prévost GP, et al. Among authors: kasprzyk pg. Cancer Res. 2006 Sep 15;66(18):9227-34. doi: 10.1158/0008-5472.CAN-05-4205. Cancer Res. 2006. PMID: 16982767

10

BN80927: a novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo.

Demarquay D, Huchet M, Coulomb H, Lesueur-Ginot L, Lavergne O, Camara J, Kasprzyk PG, Prévost G, Bigg DC. Demarquay D, et al. Among authors: kasprzyk pg. Cancer Res. 2004 Jul 15;64(14):4942-9. doi: 10.1158/0008-5472.CAN-03-3872. Cancer Res. 2004. PMID: 15256467

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