Hamel E - Search Results

1

Synthesis, antitubulin, and antiproliferative SAR of C3/C1-substituted tetrahydroisoquinolines.

Dohle W, Leese MP, Jourdan FL, Major MR, Bai R, Hamel E, Ferrandis E, Kasprzyk PG, Fiore A, Newman SP, Purohit A, Potter BV. Dohle W, et al. Among authors: hamel e. ChemMedChem. 2014 Feb;9(2):350-70. doi: 10.1002/cmdc.201300412. Epub 2014 Jan 16. ChemMedChem. 2014. PMID: 24436228

2

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.

Bai R, Friedman SJ, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1992 Jun 23;43(12):2637-45. doi: 10.1016/0006-2952(92)90153-a. Biochem Pharmacol. 1992. PMID: 1632820

3

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. J Biol Chem. 1991 Aug 25;266(24):15882-9. J Biol Chem. 1991. PMID: 1874739 Free article.

4

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. J Biol Chem. 1990 Oct 5;265(28):17141-9. J Biol Chem. 1990. PMID: 2211617 Free article.

5

Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. Biochem Pharmacol. 1990 Oct 15;40(8):1859-64. doi: 10.1016/0006-2952(90)90367-t. Biochem Pharmacol. 1990. PMID: 2242019

6

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.

Bai R, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1990 Jun 15;39(12):1941-9. doi: 10.1016/0006-2952(90)90613-p. Biochem Pharmacol. 1990. PMID: 2353935

7

Mechanism of action of the antimitotic drug 2,4-dichlorobenzyl thiocyanate: alkylation of sulfhydryl group(s) of beta-tubulin.

Bai R, Duanmu C, Hamel E. Bai R, et al. Among authors: hamel e. Biochim Biophys Acta. 1989 Jan 19;994(1):12-20. doi: 10.1016/0167-4838(89)90056-3. Biochim Biophys Acta. 1989. PMID: 2909252

The compound, 2,4-dichlorobenzyl thiocyanate (DCBT) was previously shown to cause mitotic arrest, disruption of intracellular microtubules, and inhibition of tubulin polymerization, with resistance to the drug conferred by a mutation in a beta-tubulin gene (Abraham, I., Dion, R.L …

The compound, 2,4-dichlorobenzyl thiocyanate (DCBT) was previously shown to cause mitotic arrest, disruption of intracellular microtubules, …

8

Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.

Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Mol Pharmacol. 1993 Oct;44(4):757-66. Mol Pharmacol. 1993. PMID: 8232226

9

Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.

Bai R, Roach MC, Jayaram SK, Barkoczy J, Pettit GR, Ludueña RF, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1993 Apr 6;45(7):1503-15. doi: 10.1016/0006-2952(93)90051-w. Biochem Pharmacol. 1993. PMID: 8471072

10

Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.

Bai R, Schwartz RE, Kepler JA, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Cancer Res. 1996 Oct 1;56(19):4398-406. Cancer Res. 1996. PMID: 8813133

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

656 results

Search Page

Filters