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Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus macaques decreases the frequency of circulating CD14+CD16++ monocytes but does not alter the tissue virus reservoir.
Moniuszko M, Liyanage NP, Doster MN, Parks RW, Grubczak K, Lipinska D, McKinnon K, Brown C, Hirsch V, Vaccari M, Gordon S, Pegu P, Fenizia C, Flisiak R, Grzeszczuk A, Dabrowska M, Robert-Guroff M, Silvestri G, Stevenson M, McCune J, Franchini G. Moniuszko M, et al. Among authors: brown c. AIDS Res Hum Retroviruses. 2015 Jan;31(1):115-26. doi: 10.1089/AID.2013.0220. AIDS Res Hum Retroviruses. 2015. PMID: 24432835 Free PMC article.
Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain.
Matsuda K, Dang Q, Brown CR, Keele BF, Wu F, Ourmanov I, Goeken R, Whitted S, Riddick NE, Buckler-White A, Hirsch VM. Matsuda K, et al. J Virol. 2014 Nov;88(22):13201-11. doi: 10.1128/JVI.01996-14. Epub 2014 Sep 3. J Virol. 2014. PMID: 25187546 Free PMC article.
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans.
Igarashi T, Brown CR, Endo Y, Buckler-White A, Plishka R, Bischofberger N, Hirsch V, Martin MA. Igarashi T, et al. Among authors: brown cr. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):658-63. doi: 10.1073/pnas.98.2.658. Epub 2001 Jan 2. Proc Natl Acad Sci U S A. 2001. PMID: 11136236 Free PMC article.
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