Niedziela-Majka A - Search Results

1

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors.

Boyce SE, Tirunagari N, Niedziela-Majka A, Perry J, Wong M, Kan E, Lagpacan L, Barauskas O, Hung M, Fenaux M, Appleby T, Watkins WJ, Schmitz U, Sakowicz R. Boyce SE, et al. PLoS One. 2014 Jan 9;9(1):e84808. doi: 10.1371/journal.pone.0084808. eCollection 2014. PLoS One. 2014. PMID: 24416288 Free PMC article.

2

New class of HIV-1 integrase (IN) inhibitors with a dual mode of action.

Tsiang M, Jones GS, Niedziela-Majka A, Kan E, Lansdon EB, Huang W, Hung M, Samuel D, Novikov N, Xu Y, Mitchell M, Guo H, Babaoglu K, Liu X, Geleziunas R, Sakowicz R. Tsiang M, et al. J Biol Chem. 2012 Jun 15;287(25):21189-203. doi: 10.1074/jbc.M112.347534. Epub 2012 Apr 25. J Biol Chem. 2012. PMID: 22535962 Free PMC article.

3

Large-scale functional purification of recombinant HIV-1 capsid.

Hung M, Niedziela-Majka A, Jin D, Wong M, Leavitt S, Brendza KM, Liu X, Sakowicz R. Hung M, et al. PLoS One. 2013;8(3):e58035. doi: 10.1371/journal.pone.0058035. Epub 2013 Mar 5. PLoS One. 2013. PMID: 23472130 Free PMC article.

4

Highly potent HCV NS4B inhibitors with activity against multiple genotypes.

Phillips B, Cai R, Delaney W, Du Z, Ji M, Jin H, Lee J, Li J, Niedziela-Majka A, Mish M, Pyun HJ, Saugier J, Tirunagari N, Wang J, Yang H, Wu Q, Sheng C, Zonte C. Phillips B, et al. J Med Chem. 2014 Mar 13;57(5):2161-6. doi: 10.1021/jm401646w. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24512292

5

Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent.

Kwon HJ, Xing W, Chan K, Niedziela-Majka A, Brendza KM, Kirschberg T, Kato D, Link JO, Cheng G, Liu X, Sakowicz R. Kwon HJ, et al. PLoS One. 2015 Apr 9;10(4):e0122844. doi: 10.1371/journal.pone.0122844. eCollection 2015. PLoS One. 2015. PMID: 25856426 Free PMC article.

6

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.

Xing W, Barauskas O, Kirschberg T, Niedziela-Majka A, Clarke M, Birkus G, Weissburg P, Liu X, Schultz BE, Sakowicz R, Kwon H, Feng JY. Xing W, et al. PLoS One. 2017 Aug 15;12(8):e0181969. doi: 10.1371/journal.pone.0181969. eCollection 2017. PLoS One. 2017. PMID: 28809961 Free PMC article.

7

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.

Khaki AR, Field C, Malik S, Niedziela-Majka A, Leavitt SA, Wang R, Hung M, Sakowicz R, Brendza KM, Fischer CJ. Khaki AR, et al. J Mol Biol. 2010 Jul 16;400(3):354-78. doi: 10.1016/j.jmb.2010.04.065. Epub 2010 May 6. J Mol Biol. 2010. PMID: 20451531 Free PMC article.

8

Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.

Balakrishnan M, Yant SR, Tsai L, O'Sullivan C, Bam RA, Tsai A, Niedziela-Majka A, Stray KM, Sakowicz R, Cihlar T. Balakrishnan M, et al. PLoS One. 2013 Sep 9;8(9):e74163. doi: 10.1371/journal.pone.0074163. eCollection 2013. PLoS One. 2013. PMID: 24040198 Free PMC article.

9

High-throughput screening of formulations to optimize the thermal stability of a therapeutic monoclonal antibody.

Niedziela-Majka A, Kan E, Weissburg P, Mehra U, Sellers S, Sakowicz R. Niedziela-Majka A, et al. J Biomol Screen. 2015 Apr;20(4):552-9. doi: 10.1177/1087057114557781. Epub 2014 Nov 10. J Biomol Screen. 2015. PMID: 25385011

10

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.

Lad L, Clancy S, Koditek D, Wong MH, Jin D, Niedziela-Majka A, Papalia GA, Hung M, Yant S, Somoza JR, Hu E, Chou C, Tse W, Halcomb R, Sakowicz R, Pagratis N. Lad L, et al. Biochemistry. 2015 Apr 7;54(13):2240-8. doi: 10.1021/acs.biochem.5b00151. Epub 2015 Mar 24. Biochemistry. 2015. PMID: 25774576

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