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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.
Yang SM, Tang Y, Rano T, Lu H, Kuo GH, Gaul MD, Li Y, Ho G, Lang W, Conway JG, Liang Y, Lenhard JM, Demarest KT, Murray WV. Yang SM, et al. Among authors: lang w. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1437-41. doi: 10.1016/j.bmcl.2013.12.075. Epub 2013 Dec 27. Bioorg Med Chem Lett. 2014. PMID: 24405703
Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents.
Du F, Hinke SA, Cavanaugh C, Polidori D, Wallace N, Kirchner T, Jennis M, Lang W, Kuo GH, Gaul MD, Lenhard J, Demarest K, Ajami NJ, Liang Y, Hornby PJ. Du F, et al. Among authors: lang w. J Pharmacol Exp Ther. 2018 Jun;365(3):676-687. doi: 10.1124/jpet.118.248575. Epub 2018 Apr 19. J Pharmacol Exp Ther. 2018. PMID: 29674332
Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.
Albarazanji K, Jennis M, Cavanaugh CR, Lang W, Singh B, Lanter JC, Lenhard JM, Hornby PJ. Albarazanji K, et al. Among authors: lang w. Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G653-G667. doi: 10.1152/ajpgi.00404.2018. Epub 2019 Mar 28. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 30920846 Free PMC article.
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.
Qi J, Lang W, Geisler JG, Wang P, Petrounia I, Mai S, Smith C, Askari H, Struble GT, Williams R, Bhanot S, Monia BP, Bayoumy S, Grant E, Caldwell GW, Todd MJ, Liang Y, Gaul MD, Demarest KT, Connelly MA. Qi J, et al. Among authors: lang w. J Lipid Res. 2012 Jun;53(6):1106-16. doi: 10.1194/jlr.M020156. Epub 2012 Apr 3. J Lipid Res. 2012. PMID: 22493088 Free PMC article.
A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice.
Greco MN, Connelly MA, Leo GC, Olson MW, Powell E, Huang Z, Hawkins M, Smith C, Schalk-Hihi C, Darrow AL, Xin H, Lang W, Damiano BP, Hlasta DJ. Greco MN, et al. Among authors: lang w. Bioorg Med Chem Lett. 2013 May 1;23(9):2595-7. doi: 10.1016/j.bmcl.2013.02.113. Epub 2013 Mar 7. Bioorg Med Chem Lett. 2013. PMID: 23528297
The IC(50) concept revisited.
Caldwell GW, Yan Z, Lang W, Masucci JA. Caldwell GW, et al. Among authors: lang w. Curr Top Med Chem. 2012;12(11):1282-90. doi: 10.2174/156802612800672844. Curr Top Med Chem. 2012. PMID: 22571790 Review.
1,477 results