Wang R - Search Results

1

Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.

Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Wagner SL, et al. Among authors: wang r. Biochemistry. 2014 Feb 4;53(4):702-13. doi: 10.1021/bi401537v. Epub 2014 Jan 22. Biochemistry. 2014. PMID: 24401146 Free PMC article.

2

A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.

Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS. Zhang X, et al. Among authors: wang r. J Biol Chem. 2014 Dec 12;289(50):34851-61. doi: 10.1074/jbc.M114.609636. Epub 2014 Oct 28. J Biol Chem. 2014. PMID: 25352592 Free PMC article.

3

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

Ikeuchi T, Dolios G, Kim SH, Wang R, Sisodia SS. Ikeuchi T, et al. Among authors: wang r. J Biol Chem. 2003 Feb 28;278(9):7010-8. doi: 10.1074/jbc.M209252200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12493731 Free article.

4

Differential release of β-amyloid from dendrite- versus axon-targeted APP.

DeBoer SR, Dolios G, Wang R, Sisodia SS. DeBoer SR, et al. Among authors: wang r. J Neurosci. 2014 Sep 10;34(37):12313-27. doi: 10.1523/JNEUROSCI.2255-14.2014. J Neurosci. 2014. PMID: 25209273 Free PMC article.

5

Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.

Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li YM, Koide S, Sisodia SS. Zhang X, et al. Among authors: wang r. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8534-9. doi: 10.1073/pnas.1202691109. Epub 2012 May 14. Proc Natl Acad Sci U S A. 2012. PMID: 22586122 Free PMC article.

6

Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ.

Fernandez MA, Biette KM, Dolios G, Seth D, Wang R, Wolfe MS. Fernandez MA, et al. Among authors: wang r. Biochemistry. 2016 Oct 11;55(40):5675-5688. doi: 10.1021/acs.biochem.6b00718. Epub 2016 Sep 30. Biochemistry. 2016. PMID: 27649271 Free PMC article.

7

APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.

Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. Tesco G, et al. Among authors: wang r. J Neurochem. 2005 Oct;95(2):446-56. doi: 10.1111/j.1471-4159.2005.03381.x. Epub 2005 Aug 8. J Neurochem. 2005. PMID: 16086682 Free article.

8

Purification and characterization of the human gamma-secretase complex.

Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS. Fraering PC, et al. Among authors: wang r. Biochemistry. 2004 Aug 3;43(30):9774-89. doi: 10.1021/bi0494976. Biochemistry. 2004. PMID: 15274632

9

Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.

Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. Shelton CC, et al. Among authors: wang r. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20228-33. doi: 10.1073/pnas.0910757106. Epub 2009 Nov 11. Proc Natl Acad Sci U S A. 2009. PMID: 19906985 Free PMC article.

10

Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages.

Majumdar A, Chung H, Dolios G, Wang R, Asamoah N, Lobel P, Maxfield FR. Majumdar A, et al. Among authors: wang r. Neurobiol Aging. 2008 May;29(5):707-15. doi: 10.1016/j.neurobiolaging.2006.12.001. Epub 2007 Jan 11. Neurobiol Aging. 2008. PMID: 17222479 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

42,308 results

Search Page

Filters