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RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder.
Akula N, Barb J, Jiang X, Wendland JR, Choi KH, Sen SK, Hou L, Chen DT, Laje G, Johnson K, Lipska BK, Kleinman JE, Corrada-Bravo H, Detera-Wadleigh S, Munson PJ, McMahon FJ. Akula N, et al. Among authors: detera wadleigh s. Mol Psychiatry. 2014 Nov;19(11):1179-85. doi: 10.1038/mp.2013.170. Epub 2014 Jan 7. Mol Psychiatry. 2014. PMID: 24393808 Free PMC article.
A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.
Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nöthen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Höfels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ. Baum AE, et al. Mol Psychiatry. 2008 Feb;13(2):197-207. doi: 10.1038/sj.mp.4002012. Epub 2007 May 8. Mol Psychiatry. 2008. PMID: 17486107 Free PMC article.
Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.
Schulze TG, Detera-Wadleigh SD, Akula N, Gupta A, Kassem L, Steele J, Pearl J, Strohmaier J, Breuer R, Schwarz M, Propping P, Nöthen MM, Cichon S, Schumacher J; NIMH Genetics Initiative Bipolar Disorder Consortium; Rietschel M, McMahon FJ. Schulze TG, et al. Mol Psychiatry. 2009 May;14(5):487-91. doi: 10.1038/mp.2008.134. Epub 2008 Dec 16. Mol Psychiatry. 2009. PMID: 19088739 Free PMC article.
Deep transcriptome sequencing of subgenual anterior cingulate cortex reveals cross-diagnostic and diagnosis-specific RNA expression changes in major psychiatric disorders.
Akula N, Marenco S, Johnson K, Feng N, Zhu K, Schulmann A, Corona W, Jiang X, Cross J, England B, Nathan A, Detera-Wadleigh S, Xu Q, Auluck PK, An K, Kramer R, Apud J, Harris BT, Harker Rhodes C, Lipska BK, McMahon FJ. Akula N, et al. Among authors: detera wadleigh s. Neuropsychopharmacology. 2021 Jun;46(7):1364-1372. doi: 10.1038/s41386-020-00949-5. Epub 2021 Feb 8. Neuropsychopharmacology. 2021. PMID: 33558674 Free PMC article.
143 results