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The IQ-CSRC prospective clinical Phase 1 study: "Can early QT assessment using exposure response analysis replace the thorough QT study?".
Darpo B, Sarapa N, Garnett C, Benson C, Dota C, Ferber G, Jarugula V, Johannesen L, Keirns J, Krudys K, Ortemann-Renon C, Riley S, Rogers-Subramaniam D, Stockbridge N. Darpo B, et al. Among authors: stockbridge n. Ann Noninvasive Electrocardiol. 2014 Jan;19(1):70-81. doi: 10.1111/anec.12128. Epub 2013 Dec 30. Ann Noninvasive Electrocardiol. 2014. PMID: 24372708 Free PMC article. Review.
Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase.
Darpo B, Benson C, Dota C, Ferber G, Garnett C, Green CL, Jarugula V, Johannesen L, Keirns J, Krudys K, Liu J, Ortemann-Renon C, Riley S, Sarapa N, Smith B, Stoltz RR, Zhou M, Stockbridge N. Darpo B, et al. Among authors: stockbridge n. Clin Pharmacol Ther. 2015 Apr;97(4):326-35. doi: 10.1002/cpt.60. Clin Pharmacol Ther. 2015. PMID: 25670536 Clinical Trial.
Practice and challenges of thorough QT studies.
Stockbridge N, Zhang J, Garnett C, Malik M. Stockbridge N, et al. J Electrocardiol. 2012 Nov-Dec;45(6):582-7. doi: 10.1016/j.jelectrocard.2012.07.020. Epub 2012 Sep 19. J Electrocardiol. 2012. PMID: 22999322 Review.
Sex differences in drug-induced changes in ventricular repolarization.
Vicente J, Johannesen L, Mason JW, Pueyo E, Stockbridge N, Strauss DG. Vicente J, et al. Among authors: stockbridge n. J Electrocardiol. 2015 Nov-Dec;48(6):1081-7. doi: 10.1016/j.jelectrocard.2015.08.004. Epub 2015 Aug 4. J Electrocardiol. 2015. PMID: 26324176 Clinical Trial.
Universal Correction for QT/RR Hysteresis.
Malik M, Johannesen L, Hnatkova K, Stockbridge N. Malik M, et al. Among authors: stockbridge n. Drug Saf. 2016 Jun;39(6):577-88. doi: 10.1007/s40264-016-0406-0. Drug Saf. 2016. PMID: 26968541
189 results