Derakhchan K - Search Results

1

Detection of QTc interval prolongation using jacket telemetry in conscious non-human primates: comparison with implanted telemetry.

Derakhchan K, Chui RW, Stevens D, Gu W, Vargas HM. Derakhchan K, et al. Br J Pharmacol. 2014 Jan;171(2):509-22. doi: 10.1111/bph.12484. Br J Pharmacol. 2014. PMID: 24372552 Free PMC article.

2

Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6 month period.

Chui RW, Derakhchan K, Vargas HM. Chui RW, et al. Among authors: derakhchan k. J Pharmacol Toxicol Methods. 2012 Sep;66(2):84-91. doi: 10.1016/j.vascn.2012.05.002. Epub 2012 May 14. J Pharmacol Toxicol Methods. 2012. PMID: 22613062

3

Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects.

Schram G, Zhang L, Derakhchan K, Ehrlich JR, Belardinelli L, Nattel S. Schram G, et al. Among authors: derakhchan k. Br J Pharmacol. 2004 Aug;142(8):1300-8. doi: 10.1038/sj.bjp.0705879. Epub 2004 Jul 26. Br J Pharmacol. 2004. PMID: 15277312 Free PMC article.

4

Pharmacological prevention of atrial tachycardia induced atrial remodeling as a potential therapeutic strategy.

Shinagawa K, Derakhchan K, Nattel S. Shinagawa K, et al. Among authors: derakhchan k. Pacing Clin Electrophysiol. 2003 Mar;26(3):752-64. doi: 10.1046/j.1460-9592.2003.00128.x. Pacing Clin Electrophysiol. 2003. PMID: 12698678 Review.

5

The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF.

Derakhchan K, Villemaire C, Talajic M, Nattel S. Derakhchan K, et al. Cardiovasc Res. 2001 Apr;50(1):75-84. doi: 10.1016/s0008-6363(00)00320-5. Cardiovasc Res. 2001. PMID: 11282080

6

Atrial ischemia promotes atrial fibrillation in dogs.

Sinno H, Derakhchan K, Libersan D, Merhi Y, Leung TK, Nattel S. Sinno H, et al. Among authors: derakhchan k. Circulation. 2003 Apr 15;107(14):1930-6. doi: 10.1161/01.CIR.0000058743.15215.03. Epub 2003 Mar 31. Circulation. 2003. PMID: 12668526

7

Method for simultaneous epicardial and endocardial mapping of in vivo canine heart: application to atrial conduction properties and arrhythmia mechanisms.

Derakhchan K, Li D, Courtemanche M, Smith B, Brouillette J, Pagé PL, Nattel S. Derakhchan K, et al. J Cardiovasc Electrophysiol. 2001 May;12(5):548-55. doi: 10.1046/j.1540-8167.2001.00548.x. J Cardiovasc Electrophysiol. 2001. PMID: 11386516

8

Effects of procainamide and propafenone on the composition of the excitable gap in canine atrial reentry tachycardia.

Derakhchan K, Pagé P, Lambert C, Kus T. Derakhchan K, et al. J Pharmacol Exp Ther. 1994 Jul;270(1):47-54. J Pharmacol Exp Ther. 1994. PMID: 8035342

9

Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).

Dineen TA, Chen K, Cheng AC, Derakhchan K, Epstein O, Esmay J, Hickman D, Kreiman CE, Marx IE, Wahl RC, Wen PH, Weiss MM, Whittington DA, Wood S, Fremeau RT Jr, White RD, Patel VF. Dineen TA, et al. Among authors: derakhchan k. J Med Chem. 2014 Dec 11;57(23):9811-31. doi: 10.1021/jm5012676. Epub 2014 Nov 14. J Med Chem. 2014. PMID: 25363711

10

Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.

Epstein O, Bryan MC, Cheng AC, Derakhchan K, Dineen TA, Hickman D, Hua Z, Human JB, Kreiman C, Marx IE, Weiss MM, Wahl RC, Wen PH, Whittington DA, Wood S, Zheng XM, Fremeau RT Jr, White RD, Patel VF. Epstein O, et al. Among authors: derakhchan k. J Med Chem. 2014 Dec 11;57(23):9796-810. doi: 10.1021/jm501266w. Epub 2014 Nov 12. J Med Chem. 2014. PMID: 25389560

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