Zhang X - Search Results

1

DW09849, a selective phosphatidylinositol 3-kinase (PI3K) inhibitor, prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110α (H1047R).

Liu JL, Gao GR, Zhang X, Cao SF, Guo CL, Wang X, Tong LJ, Ding J, Duan WH, Meng LH. Liu JL, et al. Among authors: zhang x. J Pharmacol Exp Ther. 2014 Mar;348(3):432-41. doi: 10.1124/jpet.113.210724. Epub 2013 Dec 20. J Pharmacol Exp Ther. 2014. PMID: 24361696

2

Crystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.

Zhao Y, Zhang X, Chen Y, Lu S, Peng Y, Wang X, Guo C, Zhou A, Zhang J, Luo Y, Shen Q, Ding J, Meng L, Zhang J. Zhao Y, et al. Among authors: zhang j, zhang x. ACS Med Chem Lett. 2013 Dec 10;5(2):138-42. doi: 10.1021/ml400378e. eCollection 2014 Feb 13. ACS Med Chem Lett. 2013. PMID: 24900786 Free PMC article.

3

Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia.

Wang X, Zhang X, Li BS, Zhai X, Yang Z, Ding LX, Wang H, Liang C, Zhu W, Ding J, Meng LH. Wang X, et al. Among authors: zhang x. Oncotarget. 2014 Nov 15;5(21):10732-44. doi: 10.18632/oncotarget.2533. Oncotarget. 2014. PMID: 25313141 Free PMC article.

4

SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.

Wei M, Zhang X, Wang X, Song Z, Ding J, Meng LH, Zhang A. Wei M, et al. Among authors: zhang a, zhang x. Eur J Med Chem. 2017 Jan 5;125:1156-1171. doi: 10.1016/j.ejmech.2016.11.014. Epub 2016 Nov 9. Eur J Med Chem. 2017. PMID: 27846451

5

Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity.

Yang C, Zhang X, Wang Y, Yang Y, Liu X, Deng M, Jia Y, Ling Y, Meng LH, Zhou Y. Yang C, et al. Among authors: zhang x. ACS Med Chem Lett. 2017 Jul 26;8(8):875-880. doi: 10.1021/acsmedchemlett.7b00222. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835805 Free PMC article.

6

New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound.

Yang X, Zhang X, Huang M, Song K, Li X, Huang M, Meng L, Zhang J. Yang X, et al. Among authors: zhang j, zhang x. Sci Rep. 2017 Nov 6;7(1):14572. doi: 10.1038/s41598-017-15260-5. Sci Rep. 2017. PMID: 29109464 Free PMC article.

7

Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors.

Yang X, Deng M, Zhang X, Wang Y, Song K, Cong R, Meng L, Zhang J. Yang X, et al. Among authors: zhang j, zhang x. Chem Biol Drug Des. 2019 Dec;94(6):2013-2022. doi: 10.1111/cbdd.13425. Epub 2019 Oct 14. Chem Biol Drug Des. 2019. PMID: 30381889

8

Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA^H1047R accompanied with pro-tumorigenic secretome.

Liu XL, Liu JL, Xu YC, Zhang X, Wang YX, Qing LH, Guo W, Ding J, Meng LH. Liu XL, et al. Among authors: zhang x. Int J Cancer. 2019 Aug 1;145(3):817-829. doi: 10.1002/ijc.32153. Epub 2019 Feb 7. Int J Cancer. 2019. PMID: 30671946

9

Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer.

Wang Y, Li X, Liu X, Chen Y, Yang C, Tan C, Wang B, Sun Y, Zhang X, Gao Y, Ding J, Meng L. Wang Y, et al. Among authors: zhang x. Cancer Biol Med. 2019 Feb;16(1):66-83. doi: 10.20892/j.issn.2095-3941.2018.0361. Cancer Biol Med. 2019. PMID: 31119047 Free PMC article.

10

PI3Kα inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment.

Shi JJ, Xing H, Wang YX, Zhang X, Zhan QM, Geng MY, Ding J, Meng LH. Shi JJ, et al. Among authors: zhang x. Cancer Lett. 2019 Sep 10;459:145-155. doi: 10.1016/j.canlet.2019.05.040. Epub 2019 Jun 4. Cancer Lett. 2019. PMID: 31173854

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