Mezo AR - Search Results

1

Neonatal Fc receptor promotes immune complex-mediated glomerular disease.

Olaru F, Luo W, Suleiman H, St John PL, Ge L, Mezo AR, Shaw AS, Abrahamson DR, Miner JH, Borza DB. Olaru F, et al. Among authors: mezo ar. J Am Soc Nephrol. 2014 May;25(5):918-25. doi: 10.1681/ASN.2013050498. Epub 2013 Dec 19. J Am Soc Nephrol. 2014. PMID: 24357670 Free PMC article.

2

Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction.

Wang Z, Fraley C, Mezo AR. Wang Z, et al. Among authors: mezo ar. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1253-6. doi: 10.1016/j.bmcl.2013.01.014. Epub 2013 Jan 11. Bioorg Med Chem Lett. 2013. PMID: 23375228

3

X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn.

Mezo AR, Sridhar V, Badger J, Sakorafas P, Nienaber V. Mezo AR, et al. J Biol Chem. 2010 Sep 3;285(36):27694-701. doi: 10.1074/jbc.M110.120667. Epub 2010 Jun 30. J Biol Chem. 2010. PMID: 20592032 Free PMC article.

4

Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction.

McDonnell KA, Low SC, Hoehn T, Donnelly R, Palmieri H, Fraley C, Sakorafas P, Mezo AR. McDonnell KA, et al. Among authors: mezo ar. J Med Chem. 2010 Feb 25;53(4):1587-96. doi: 10.1021/jm901128z. J Med Chem. 2010. PMID: 20092334

5

PEGylation enhances the therapeutic potential of peptide antagonists of the neonatal Fc receptor, FcRn.

Mezo AR, Low SC, Hoehn T, Palmieri H. Mezo AR, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6332-5. doi: 10.1016/j.bmcl.2011.08.111. Epub 2011 Aug 31. Bioorg Med Chem Lett. 2011. PMID: 21920737

6

Inhibitors of the FcRn:IgG protein-protein interaction.

Low SC, Mezo AR. Low SC, et al. Among authors: mezo ar. AAPS J. 2009 Sep;11(3):432-4. doi: 10.1208/s12248-009-9120-5. Epub 2009 Jun 5. AAPS J. 2009. PMID: 19499344 Free PMC article. Review.

7

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn.

Mezo AR, McDonnell KA, Hehir CA, Low SC, Palombella VJ, Stattel JM, Kamphaus GD, Fraley C, Zhang Y, Dumont JA, Bitonti AJ. Mezo AR, et al. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2337-42. doi: 10.1073/pnas.0708960105. Epub 2008 Feb 12. Proc Natl Acad Sci U S A. 2008. PMID: 18272495 Free PMC article.

8

Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates.

Nixon AE, Chen J, Sexton DJ, Muruganandam A, Bitonti AJ, Dumont J, Viswanathan M, Martik D, Wassaf D, Mezo A, Wood CR, Biedenkapp JC, TenHoor C. Nixon AE, et al. Front Immunol. 2015 Apr 23;6:176. doi: 10.3389/fimmu.2015.00176. eCollection 2015. Front Immunol. 2015. PMID: 25954273 Free PMC article.

9

Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.

Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Pyzik M, et al. Among authors: mezo ar. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2862-E2871. doi: 10.1073/pnas.1618291114. Epub 2017 Mar 22. Proc Natl Acad Sci U S A. 2017. PMID: 28330995 Free PMC article.

10

Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction.

Mezo AR, McDonnell KA, Castro A, Fraley C. Mezo AR, et al. Bioorg Med Chem. 2008 Jun 15;16(12):6394-405. doi: 10.1016/j.bmc.2008.05.004. Epub 2008 May 6. Bioorg Med Chem. 2008. PMID: 18501614

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