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Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.
Murai J, Huang SY, Das BB, Renaud A, Zhang Y, Doroshow JH, Ji J, Takeda S, Pommier Y. Murai J, et al. Among authors: huang sy. Cancer Res. 2012 Nov 1;72(21):5588-99. doi: 10.1158/0008-5472.CAN-12-2753. Cancer Res. 2012. PMID: 23118055 Free PMC article.
Biochemical assays for the discovery of TDP1 inhibitors.
Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y. Marchand C, et al. Among authors: huang sy. Mol Cancer Ther. 2014 Aug;13(8):2116-26. doi: 10.1158/1535-7163.MCT-13-0952. Epub 2014 Jul 14. Mol Cancer Ther. 2014. PMID: 25024006 Free PMC article.
Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).
Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C. Pommier Y, et al. Among authors: huang sy. DNA Repair (Amst). 2014 Jul;19:114-29. doi: 10.1016/j.dnarep.2014.03.020. Epub 2014 May 22. DNA Repair (Amst). 2014. PMID: 24856239 Free PMC article. Review.
PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.
Das BB, Huang SY, Murai J, Rehman I, Amé JC, Sengupta S, Das SK, Majumdar P, Zhang H, Biard D, Majumder HK, Schreiber V, Pommier Y. Das BB, et al. Among authors: huang sy. Nucleic Acids Res. 2014 Apr;42(7):4435-49. doi: 10.1093/nar/gku088. Epub 2014 Feb 3. Nucleic Acids Res. 2014. PMID: 24493735 Free PMC article.
Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.
Khiati S, Baechler SA, Factor VM, Zhang H, Huang SY, Dalla Rosa I, Sourbier C, Neckers L, Thorgeirsson SS, Pommier Y. Khiati S, et al. Among authors: huang sy. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11282-7. doi: 10.1073/pnas.1511016112. Epub 2015 Aug 24. Proc Natl Acad Sci U S A. 2015. PMID: 26305952 Free PMC article.
2,292 results