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Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1).
Nies AT, Schaeffeler E, van der Kuip H, Cascorbi I, Bruhn O, Kneba M, Pott C, Hofmann U, Volk C, Hu S, Baker SD, Sparreboom A, Ruth P, Koepsell H, Schwab M. Nies AT, et al. Among authors: bruhn o. Clin Cancer Res. 2014 Feb 15;20(4):985-94. doi: 10.1158/1078-0432.CCR-13-1999. Epub 2013 Dec 18. Clin Cancer Res. 2014. PMID: 24352644 Free PMC article.
Expression differences of miR-142-5p between treatment-naïve chronic myeloid leukemia patients responding and non-responding to imatinib therapy suggest a link to oncogenic ABL2, SRI, cKIT and MCL1 signaling pathways critical for development of therapy resistance.
Klümper T, Bruckmueller H, Diewock T, Kaehler M, Haenisch S, Pott C, Bruhn O, Cascorbi I. Klümper T, et al. Among authors: bruhn o. Exp Hematol Oncol. 2020 Sep 26;9:26. doi: 10.1186/s40164-020-00183-1. eCollection 2020. Exp Hematol Oncol. 2020. PMID: 32999756 Free PMC article.
Challenges in pharmacogenetics.
Cascorbi I, Bruhn O, Werk AN. Cascorbi I, et al. Among authors: bruhn o. Eur J Clin Pharmacol. 2013 May;69 Suppl 1:17-23. doi: 10.1007/s00228-013-1492-x. Epub 2013 May 3. Eur J Clin Pharmacol. 2013. PMID: 23640184 Review.
17 results